Anti-SENP6 Anticorpo 79-Mé um anticorpo monoclonal produzido em camundongo IgG2a κ SENP6 anticorpo, citado em 4 publicações, fornecido em 100 µg/ml
Produzido contra recombinante SENP6 de human origem
recomendado para a detecção de SENP6 of human origin by WB, IP, IF, IHC(P) and ELISA
Entre em contato conosco e receba GRATUITAMENTE um amostra de 10 µg de SENP6 (79-M): sc-100585.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred secondary detection reagent for SENP6 Antibody (79-M) for WB and IHC(P) applications. This reagent is now offered in a bundle with SENP6 Antibody (79-M) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Labware ships FedEx Ground free of charge to the contiguous US
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SENP6 Antibody (79-M) is a high quality monoclonal SENP6 antibody suitable for the detection of the SENP6 protein of human origin. SENP6 Antibody (79-M) is available as the non-conjugated anti-SENP6 antibody. SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins, including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the "GG" region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates. HIPK2 is a desumoylation target for SENP1 which shuttles between the cytoplasm and the nucleus. Mutation analyses reveal that SENP1 contains the nuclear export sequence (NES) within the extreme carboxyl-terminal region, and SENP1 is exported to the cytoplasm in a NES-dependent manner. SENP2 has been implicated as a downregulator of CTNNB1 levels and may therefore be a modulator of the Wnt pathway. SUMO protease SENP3 reverses the sumoylation of MEF2 to augment its transcriptional and myogenic activities. SENP5 localizes to the nucleolus and preferentially processes SUMO-3. It is thought to play a role in mitosis and/or cytokinesis. SENP6 localizes to the cytoplasm and releases SUMO-1. Expression of SENP6 is higher in reproductive organs, indicating that it may mediate processes related to reproduction. SENP8 is involved in the release of sentrins.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.