[Sar-9, Met(O2)-11]-Substance P CAS: 110880-55-2
MF: C64H100N18O15S
MW: 1393.7
A selective NK1 receptor agonist.

[Sar-9, Met(O2)-11]-Substance P (CAS 110880-55-2)

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Aplicação [Sar-9, Met(O2)-11]-Substance P is a selective NK1 receptor agonist
Numero VAT: 110880-55-2
Privada: >97%
Peso Molecular: 1393.7
Separar por Funcao: C64H100N18O15S
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
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Sar-9, Met(O2)-11]-Substance P is a highly selective NK-1R (NK-1 neurokinin receptor) agonist which stimulates endocytosis of NK-1 receptors but has minimal effect on NK-3 receptors. Studies suggest that this peptide does not insert into neutral or negatively charged lipid bilayers and densely packed lipid monolayers at surface pressures greater than 31 mN/m. Furthermore, in vitro tests show that Sar-9, Met(O2)-11]-Substance P augments the release of vasopressin from the hypothalamo-neurohypophysial system.


Referencias

1. Tousignant, C., et al. 1990. Brain Res. 524: 263-270. PMID: 1705465
2. Seelig, A. 1992. Biochemistry. 31: 2897-2904. PMID: 1372515
3. Yip, J. and Chahl, L.A. 1999. Neuroscience. 94: 663-673. PMID: 10579226
4. Jenkinson, K.M., et al. 2000. Neuroscience. 100: 191-199. PMID: 10996469
5. Hood, V.C., et al. 2000. Regul. Pept. 96: 17-21. PMID: 11102647
6. Juszczak, M., et al. 2007. J. Physiol. Pharmacol. 58: 829-843. PMID: 18195491

Estado físico :
Solid
envie :
Soluble in water (1 mg/ml), and 5% acetic acid.
Manutencao :
Store at -20° C
Densidade :
~1.44 g/cm3 (Predicted)
Indice de produtos :
n20D 1.66
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
PubChem CID :
Numero de FAX :
MFCD00076787
SMILES :
CC(C)CC(C(=O)NC(CCS(=O)(=O)C)C(=O)N)NC(=O)CN(C)C(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N

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