PKI (5-24), PKA Inhibitor PKI (5-24), PKA Inhibitor is a potent, competitive, synthetic peptide PKA inhibitor.

PKI (5-24), PKA Inhibitor (CAS 99534-03-9)

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Nomes alternativos: L-threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-a-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylgl ycyl-L-arginyl-L-threonylglycyl-larginyl-L-aspartic acid
Aplicação PKI (5-24), PKA Inhibitor is a potent, competitive, synthetic peptide PKA inhibitor
Numero VAT: 99534-03-9
Privada: ≥95%
Peso Molecular: 2222.37
Separar por Funcao: C94H148N32O31
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
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PKI (5-24), PKA Inhibitor is a potent, competitive, synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase) derived from the active domain of the naturally-occurring heat-stable inhibitor protein PKI. This pseudosubstrate inhibitor peptide mimics the protein substrate by binding to the catalytic site via the arginine-cluster basic subsite, which provides high specificity. PKA catalytic subunit residues Tyr235 and Phe239 form a sandwich-like structure with residue Phe10 of PKI (5-24); this is a prominent enzyme-substrate interaction site. PKI (5-24) exhibits a Ki of 2.3 nM with respect to PKA and is an extremely weak inhibitor of cGMP-dependent protein kinase (PKG).


Referencias

1. Cheng, H.C., et al. 1986. J. Biol. Chem. 261: 989-992. PMID: 3511044
2. Knighton, D.R., et al. 1991. Science. 253: 414-420. PMID: 1862343
3. Bossemeyer, D., et al. 1993. EMBO J. 12: 849-859. PMID: 8384554
4. Ruth, P., et al. 1996. Biol. Chem. 377: 513-520. PMID: 8922286
5. Narayana, N., et al. 1997. Biochemistry. 36: 4438-4448. PMID: 9109651

Paginas :
Dissolve peptide in distilled water first. The concentration should be high enough to allow for the addition of buffer after the product is dissolved completely.

If necessary, a few drops of dilute acetic acid or ammonium hydroxide can be added to help solubilize the peptide.

The solution can be sonicated briefly to help solubility. For storage, solutions should be in the pH range of 5-7.0, aliquoted and stored at -20°C or lower. Solutions can be stored for approximately 3 to 4 months.
Estado físico :
Solid
Sequencia :
Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp
envie :
Soluble in water.
Manutencao :
Store at -20° C
Data ki :
PKA: Ki= 2.3 nM
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
PubChem CID :
Numero de FAX :
MFCD00133989
SMILES :
CC[[email protected]](C)[[email protected]@H](C(=O)N[[email protected]@H](CC1=CN=CN1)C(=O)N[[email protected]@H](CC(=O)O)C(=O)O)NC(=O)[[email protected]](C)NC(=O)[[email protected]](CC(=O)N)NC(=O)[[email protected]](CCCNC(=N)N)NC(=O)[[email protected]](CCCNC(=N)N)NC(=O)CNC(=O)[[email protected]](C(C)O)NC(=O)[[email protected]](CCCNC(=N)N)NC(=O)CNC(=O)[[email protected]](CO)NC(=O)[[email protected]](C)NC(=O)[[email protected]]([[email protected]@H](C)CC)NC(=O)[[email protected]](CC2=CC=CC=C2)NC(=O)[[email protected]](CC(=O)O)NC(=O)[[email protected]](C)NC(=O)[[email protected]](CC3=CC=C(C=C3)O)NC(=O)[[email protected]](C(C)O)NC(=O)[[email protected]](C(C)O)N

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PKI (5-24), PKA Inhibitor (CAS 99534-03-9)  Citacoes dos Produtos

Visualizar com outras pessoas usaram PKI (5-24), PKA Inhibitor (CAS 99534-03-9). Clique em PubMed para ver .

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PMID: # 33450889  Azevedo Voltarelli, V.|Coronado, M.|Gonçalves Fernandes, L.|Cruz Campos, J.|Jannig, PR.|Batista Ferreira, JC.|Fajardo, G.|Chakur Brum, P.|Bernstein, D.| et al. 2021. Cells. 10:

PMID: # 26593676  Seo, J. et al. 2016. Free Radic. Biol. Med. 90: 133-44.

PMID: # 27678415  Zuo, W. et al. 2016. Neuropharmacology.

PMID: # 26537248  Alazami, AM. et al. 2015. Genome Biol. 16: 240.

PMID: # 26283508  Zuo, W. et al. 2015. Addict Biol.

PMID: # 24569881  Arakel, EC. et al. 2014. J. Cell. Sci. 127: 2106-19.

PMID: # 25367782  2014. Cell Biochem. Funct. 32: 692-701.

PMID: # 24825897  Kang, Q. et al. 2014. The Journal of biological chemistry. 289: 17480-96.

PMID: # 22796382  Campo, GM. et al. 2012. Matrix Biol. 31: 338-51.

PMID: # 10390370  Westphal, RS. et al. 1999. Science. 285: 93-96.

Citações 1 para 10 de 14 total
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