patched/PTCH1 Anticorpo A-2é um anticorpo monoclonal produzido em camundongo IgG2a κ, citado em 1 publicações, fornecido em 200 µg/ml
specific for an epitope mapping between amino acids 1401-1429 within a C-terminal cytoplasmic domain of patched of human origin
patched/PTCH1 Anticorpo (A-2) é recomendado para a detecção de patched of human origin by WB, IP, IF and ELISA
Anti-patched/PTCH1 Antibody (A-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for patched/PTCH1 Antibody (A-2) for WB applications. These reagents are now offered in bundles with patched/PTCH1 Antibody (A-2) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
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Overexpression of either Wnt-1 or the GLI proteins have been shown to result in cancer. These proteins exist in a signal cascade downstream of the mammalian homologs of the Drosophila hedgehog (hh) and patched (ptc) proteins. The hedgehog protein mediates embryonic and imaginal disc patterning, and patched expression is precisely regulated during embryonic development. Hedgehog enhances the expression of the Wnt family of proteins through a signaling cascade involving the GLI transcription factors, while patched functions as a repressor opposing the effects of hedgehog. Mutations in the ptc gene, which result in unregulated hedgehog signaling, correlates with the most common type of cancer, basal cell carcinoma, which affects 750,000 individuals annually in the United States. An additional patched family member, patched 2, has been found to be coexpressed with Sonic hedgehog.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
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