Neurokinin A CAS: 86933-74-6
MF: C50H80N14O14S
MW: 1133.33
An endogenous tachykinin agonist with preference for the NK-2R.

Neurokinin A (CAS 86933-74-6)

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Neurokinin A is rated 5.0 out of 5 by 1.
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Nomes alternativos: Substance K; Neuromedin L
Aplicação Neurokinin A is an endogenous tachykinin agonist with preference for the NK-2R
Numero VAT: 86933-74-6
Peso Molecular: 1133.33
Separar por Funcao: C50H80N14O14S
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
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Neurokinin A is a member of the endogenous tachykinin agonist with preference for the NK-2R (NK-2 receptor) with greater potency as a bronchoconstrictor than Substance P (sc-201169). The comound has shown to be identical to substance K and neuromedin L1. Neurokinin A has been reported to effect reproduction by controlling at the hypothalamus level gonadotropin and prolactin secretion along with steroid secretion at the ovarian and gonadal level. An increase in inositol 1,4,5-trisphosphate (IP3) levels along with paralleled increase in intracellular free Ca2+ in BHK-21 cells with the NK-2R gene were stimulated with Neurokinin A. The compound has also been observed to induce contraction in muscle strips and single cells of the human sigmoid colon circular muscle. Neurokinin A has also been used to discover the location of tachykinin receptors.


Referencias

1. Eistetter, H.R., et al. 1993. J. Cell. Biochem. 52: 84-91. PMID: 8391539
2. Debeljuk, L. and Lasaga, M. 1999. Peptides. 20: 285-299. PMID: 10422885
3. Cao, W., et al. 2000. Gastroenterology. 119: 51-61. PMID: 10889154

Estado físico :
Solid
envie :
Soluble in water (1 g/l) at 20° C, 10% acetonitrile / water (1 mg/ml), and 5% Acetic Acid.
Manutencao :
Store at -20° C
Ponto de fervura :
~1610.7° C at 760 mmHg (Predicted)
Densidade :
~1.3 g/cm3 (Predicted)
Indice de produtos :
n20D 1.58
Reatividade :
α20/D -57.4°, c = 0.37 in 1 M AcOH
IC50 :
Neurokinin 2 receptor: IC50 = 1 nM (human); Neurokinin 1 receptor: IC50 = 3.5 nM (human); Neurokinin 3 receptor: IC50 = 45 nM (human)
Data ki :
Neurokinin 2 receptor: Ki= 0.71 nM (human); Neurokinin 1 receptor: Ki= 630 nM (human)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
PubChem CID :
Numero de FAX :
MFCD00167560
SMILES :
CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N

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