alpha 1 Sodium Potassium ATPase/ATP1A1 Anticorpo 0.T.1é um anticorpo monoclonal produzido em camundongo IgG1 κ, citado em 14 publicações, fornecido em 200 µg/ml
raised against purified rabbit renal outer medulla
recomendado para a detecção de Na+/K+-ATPase α1 of broad species origin by WB, IP, IF and IHC(P)
See alpha 1 Sodium Potassium ATPase/ATP1A1 (C464.6): sc-21712 for additional antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for alpha 1 Sodium Potassium ATPase/ATP1A1 Antibody (0.T.1) for WB and IHC(P) applications. These reagents are now offered in bundles with alpha 1 Sodium Potassium ATPase/ATP1A1 Antibody (0.T.1) (see ordering information below).
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The ubiquitously expressed sodium/potassium-ATPase (Na+/K+-ATPase) exists as a oligomeric plasma membrane complex that couples the hydrolysis of one molecule of ATP to the importation of three Na+ ions and two K+ ions against their respective electrochemical gradients. As a member of the P-type family of ion motives, Na+/K+-ATPase plays a critical role in maintaining cellular volume, resting membrane potential and Na+-coupled solute transport. Multiple isoforms of three subunits, α, β and γ, comprise the Na+/K+-ATPase oligomer. The α subunit contains the binding sites for ATP and the cations; the glycosylated β subunit ensures correct folding and membrane insertion of the α subunits. The small γ subunit co-localizes with the α subunit in nephron segments, where it increases the affinity of Na+/K+-ATPase for ATP. The β subunit, but not the γ subunit, is essential for normal activity of Na+/K+-ATPase.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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