Mitomycin C CAS: 50-07-7
MF: C15H18N4O5
MW: 334.33
A DNA crosslinking agent that inhibits DNA synthesis, induces apoptosis in a variety of cells, and activates caspase.

Mitomycin C (CAS 50-07-7)

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Nomes alternativos: Mitomycin C also known as Mitocin-C; Ametycine; Mutamycin; Mitomycin C from Streptomyces caespitosus ;7-amino-9-alpha-methoxymitosane azirino(2′,3′:3,4)pyrrolo(1,2-a)indole-4,7-dione,6-amino-8-(((aminocarbonyl)oxy azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione,6-amino-8-[[(aminocarbonyl)ox mitomycine
Aplicação Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis, induces apoptosis in a variety of cells, and activates caspase
Numero VAT: 50-07-7
Privada: ≥99%
Peso Molecular: 334.33
Separar por Funcao: C15H18N4O5
Informação complementar: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).

Mitomycin C is part of a family of azidine natural products. It is a DNA crosslinking and damaging agent, making it a useful antibiotic and antitumor compound. When crosslinking, Mitomycin C displays absolute specificity and high efficiency for the CpG sequence. Mammalian Cells treated with Mitomycin C (0.4 mg/mL for 5 min) can undergo apoptosis through upregulation of Bad, Fas, FasL and phosphorylated p53 along with activation of caspase-3, caspase-8, and caspase-9 activating both the intrinsic and extrinsic pathway for apoptosis.


Referencias

1. Tomasz, M., et al. 1987. Science. 235: 1204-1208. PMID: 3103215

2. Tomasz, M.,et al. 1988. Biochemistry. 27: 3182-3187. PMID: 3134045

3. Tomasz, M. 1995. Chem. Biol. 2: 575-579. PMID: 9383461

4. Merlo, G.R., et al. 1995. J. Cell Biol. 128: 1185-1196. PMID: 7896881

5. Yoon, Y.S. ,et al. 1996. J. Biol. Chem. 271: 9129-9134. PMID: 8621564

6. Seong, G.J., et al. 2005. Invest. Ophthalmol. Vis. Sci. 46: 3545-3552. PMID: 16186332

Paginas :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month. Protect from light, moisture sensitive.
Aparência :
Powder
Estado físico :
Solid
Derivado de :
Streptomyces caespitosus
envie :
Soluble in water (0.5 mg/ml), 100% ethanol (warm) (1 mg/ml), DMSO (15 mg/ml), and methanol.
Manutencao :
Store at -20° C
Ponto de fusão :
>360° C
Ponto de fervura :
~581.8° C at 760 mmHg (Predicted)
Densidade :
~1.6 g/cm3 (Predicted)
Indice de produtos :
n20D 1.68 (Predicted)
IC50 :
Cytotoxicity against PC3 cells : EC5050 = 0.14 µM (human); Cytotoxicity against A549 cells: EC5050 = 0.43 µM (human); 2780/DOX ovarian cancer cell line: IC50 = 0.2 µM; promyelocytic leukemic (HL-60) cells: IC50 = 0.05 µM (human); SMMC-7721 (Hepatocellular carcinoma cells): IC50 = 2.44 µg/ml (Homo sapiens); P388 (Lymphoma cells): IC50 = 0.01 µg/ml (Mus musculus)
Valores de pK :
pKa: 3.2, 6.5, 13.27, pKb: 5.08
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
RTECS :
CN0700000
PubChem CID :
Indice de produtos :
14: 6215
Numero de FAX :
MFCD00078109
Numero de FAX :
200-008-6
Registro Beilstein :
7231816
SMILES :
CC1=C(C(=O)C2=C(C1=O)N3C[[email protected]]4[[email protected]@H]([[email protected]@]3([[email protected]@H]2COC(=O)N)OC)N4)N

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Mitomycin C (CAS 50-07-7)  Citacoes dos Produtos

Visualizar com outras pessoas usaram Mitomycin C (CAS 50-07-7). Clique em PubMed para ver .

Citações 1 para 10 de 69 total

PMID: # 33929593  Förster, A.|Brand, F.|Banan, R.|Hüneburg, R.|Weber, CAM.|Ewert, W.|Kronenberg, J.|Previti, C.|Elyan, N.|Beyer, U.|Martens, H.|Hong, B.|Bräsen, JH.|Erbersdobler, A.|Krauss, JK.|Stangel, M.|Samii, A.|Wolf, S.|Preller, M.|Aretz, S.|Wiese, B.|Hartmann, C.|Weber, RG.| et al. 2021. Acta Neuropathol.

PMID: # 33761606  Russo, R.|Santarcangelo, C.|Badolati, N.|Sommella, E.|De Filippis, A.|Dacrema, M.|Campiglia, P.|Stornaiuolo, M.|Daglia, M.| et al. 2021. Biomed Pharmacother. 137: 111385.

PMID: # 33567288  Calero-Cuenca, FJ.|Osorio, DS.|Carvalho-Marques, S.|Sridhara, SC.|Oliveira, LM.|Jiao, Y.|Diaz, J.|Janota, CS.|Cadot, B.|Gomes, ER.| et al. 2021. Curr Biol.

PMID: # 33810010  Lehto, J.|Huguet Ninou, A.|Chioureas, D.|Jonkers, J.|Gustafsson, NMS.| et al. 2021. Cancers (Basel). 13:

PMID: # 31486569  Carvajal, F.|Duran, C.|Aquea, F.| et al. 2020. J Cosmet Dermatol. 19: 1254-1259.

PMID: # 31270152  McKinney, A.|Lindberg, OR.|Engler, JR.|Chen, KY.|Kumar, A.|Gong, H.|Lu, KV.|Simonds, EF.|Cloughesy, TF.|Liau, LM.|Prados, M.|Bollen, AW.|Berger, MS.|Shieh, JTC.|James, CD.|Nicolaides, TP.|Yong, WH.|Lai, A.|Hegi, ME.|Weiss, WA.|Phillips, JJ.| et al. 2019. Mol. Cancer Ther.

PMID: # 31009828  Vancurova, M.|Hanzlikova, H.|Knoblochova, L.|Kosla, J.|Majera, D.|Mistrik, M.|Burdova, K.|Hodny, Z.|Bartek, J.| et al. 2019. DNA Repair (Amst.). 78: 114-127.

PMID: # 30381489  Guidry, JT. et al. 2018. J. Virol.

PMID: # 29978866  Tronser, T.|Demir, K.|Reischl, M.|Bastmeyer, M.|Levkin, PA.| et al. 2018. Lab Chip. 18: 2257-2269.

PMID: # 29669822  Song, X.|Lee, DH.|Dilly, AK.|Lee, YS.|Choudry, HA.|Kwon, YT.|Bartlett, DL.|Lee, YJ.| et al. 2018. Mol. Cancer Res. 16: 1077-1091.

Citações 1 para 10 de 69 total
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