Hypoxanthine can be used as a marker for energy perturbation in hypoxia/ischemia and is structurally related to 6-mercaptopurine. The compound has been used in studies as in indicator, along with uric acid (sc-213135) and allantoin (sc-207271), of in vivo free radical reactions. To understand its biological implications, hypoxanthine has been used in DNA studies to investigate the destabilizing effect it has on DNA duplexes containing hypoxanthine as a base, in a gas phase versus a liquid phase. Hypoxanthine has also been used in studies along with 8-oxoguanine nucleotides to investigate their interaction with human DNA pol α (DNA polymerase alpha) and DNA polymerase I from Bacillus stearothermophilus.
1. Marklund, N., et al. 2000. Acta Neurochir. 142: 1135-1141. PMID: 11129536
2. Patro, J.N., et al. 2009. Biochemistry. 48: 8271-8278. PMID: 19642651
3. Malináková, K., et al. 2010. J Phys Chem A. 114: 1985-1995. PMID: 20055404
4. Sun, X. and Lee, J.K. 2010. J. Org. Chem. 75: 1848-1854. PMID: 20184296
Visualizar com outras pessoas usaram Hypoxanthine (CAS 68-94-0). Clique em PubMed para ver .
PMID: # 15811855 Druzhyna, NM. et al. 2005. J. Biol. Chem. 280: 21673-21679.
PMID: # 15452132 Jana, A. et al. 2004. J. Biol. Chem. 279: 51451-51459.