HA14-1 is a small, cell-permeable nonpeptidic ligand that binds to the Bcl-2 surface pocket and blocks its biological action. HA14-1 induces apoptosis in HL-60 leukemic cells overexpressing Bcl-2 and in NIH 3T3 cells via the activation of caspases by a mechanism that is distinct from Fas-mediated apoptosis.
1. Wang, J.L., et al. 2000. Proc. Natl. Acad. Sci. U.S.A. 97: 7124-7129. PMID: 10860979
Soluble in DMSO (26 mg/mL), ethanol (100 mM), DMF, and halogenated solvents .
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