Fibronectin Inhibitor CAS: 91037-65-9
MF: C15H27N7O8
MW: 433.40
A tetrapeptide that supports fibroblast attachment and inhibits fibronectin binding.

Fibronectin Inhibitor (CAS 91037-65-9)

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Nomes alternativos: Fibronectin tetrapeptide; H-Arg-Gly-Asp-Ser-OH
Aplicação Fibronectin Inhibitor is a tetrapeptide that supports fibroblast attachment and inhibits fibronectin binding
Numero VAT: 91037-65-9
Privada: ≥97%
Peso Molecular: 433.40
Separar por Funcao: C15H27N7O8
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
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Fibronectin Inhibitor is a tetrapeptide which supports fibroblast attachment and inhibits fibronectin binding to platelets. Also an integrin binding sequence that inhibits integrin receptor function. Has been shown to decrease systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. Has been also shown to promote cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro . Known to be a target sequence for syphilis spirochete adherence.


Referencias

1. Pierschbacher, M.D., et al. 1984. Nature. 309: 30-33. PMID: 6325925
2. Haverstick, D.M., et al. 1985. Blood. 66: 946-952. PMID: 3876125
3. Ginsberg, M., et al. 1985. J. Biol. Chem. 260: 3931-3936. PMID: 3980461
4. Thomas, D.D., et al. 1985. J. Exp. Med. 162: 1715-1719. PMID: 3903025
5. Perlot, R.L., et al. 2002. J. Bone Miner. Res. 17: 66-76. PMID: 11771671
6. Grigoriou, V., et al. 2005. J. Biol. Chem. 280: 1733-1739. PMID: 15522882
7. Droppelmann, C.A., et al. 2009. J. Biol. Chem. 284: 13551-13561. PMID: 19276073
8. Moon, C., et al. 2009. Respir. Res. 10: 18. PMID: 19272161

Aparência :
Powder
Estado físico :
Solid
envie :
Soluble in water (1 mg/ml), yielding a clear, colorless solution.
Manutencao :
Store at -20° C
Ponto de fusão :
349.84° C (Predicted)
Densidade :
~1.7 g/cm3 (Predicted)
Indice de produtos :
n20D 1.66 (Predicted)
IC50 :
Integrin beta-3: IC50 = 0.18 µM (human); Integrin alpha-IIb: IC50 = 0.18 µM (human); Fibronectin receptor alpha: IC50 = 2.2 µM (human); Fibronectin receptor beta: IC50 = 2.2 µM (human)
Valores de pK :
pKa: 2.85 (Predicted), pKb: 13.38 (Predicted)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
PubChem CID :
Numero de FAX :
MFCD00076452
SMILES :
C(C[[email protected]@H](C(=O)NCC(=O)N[[email protected]@H](CC(=O)O)C(=O)N[[email protected]@H](CO)C(=O)O)N)CN=C(N)N

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Fibronectin Inhibitor (CAS 91037-65-9)  Citacoes dos Produtos

Visualizar com outras pessoas usaram Fibronectin Inhibitor (CAS 91037-65-9). Clique em PubMed para ver .

Citações 1 para 3 de 3 total

PMID: # 33514748  Munir, H.|Jones, JO.|Janowitz, T.|Hoffmann, M.|Euler, M.|Martins, CP.|Welsh, SJ.|Shields, JD.| et al. 2021. Nat Commun. 12: 683.

PMID: # 28102225  Sorrentino, G. et al. 2017. Nat Commun. 8: 14073.

PMID: # 8416943  Heemskerk, JW. et al. 1993. J. Biol. Chem. 268: 356-363.

Citações 1 para 3 de 3 total
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