Dolastatin 15 is a member of the dolastatin family. Dolastatins are marine natural products isolated from the sea hare Dolabella auricularia with a structure related to Dolastin 10. Dolastatin 15 is an anti-neoplastic pseudopeptide that inhibits Tubulin-dependent GTP hydrolysis to Tubulin but has been shown to bind to the RZX/MAY region. The compound acts as a weak Tubulin inhibitor by binding to the vinca domain of tubulin and induces apoptosis through Bcl-2 phosphorylation in several malignant cell types. Potent inhibitor of the proliferation of murine and cancer cell lines as well as that of hematopoietic progenitor cells. When added to leukemia cultures Dolastin 15 inhibited both immunoglobulin production and cell proliferation.
|Purity (HPLC)||≥ 98%|
Exp. Date: 6/18/2024
Visualizar com outras pessoas usaram Dolastatin 15 (CAS 123884-00-4). Clique em PubMed para ver .
PMID: 25633196 | Cell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1. | Cho, YC. et al. 2015. Cell Death Differ. 22: 1605-17.
PMID: 23872169 | Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation. | Piplani, H. et al. 2013. Biochimica et biophysica acta. 1830: 5142-56.
PMID: 22623379 | Up-regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of COX-2 inhibitor, Celecoxib and Dolastatin 15, a marine mollusk linear peptide in experimental colon carcinogenesis. | Piplani, H. et al. 2013. Mol. Carcinog. 52: 845-58.
PMID: 22441428 | Dolastatin 15, a mollusk linear peptide, and Celecoxib, a selective cyclooxygenase-2 inhibitor, prevent preneoplastic colonic lesions and induce apoptosis through inhibition of the regulatory transcription factor NF-κB and an inflammatory protein, iNOS. | Piplani, H. et al. 2012. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 21: 511-22.