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Dolastatin 15 | CAS 123884-00-4 | SCBT - Santa Cruz Biotechnology
Dolastatin 15 CAS: 123884-00-4
Dolastatin 15 is an apoptotic agent through Blc-2 phosphorylation.

Dolastatin 15 (CAS 123884-00-4)

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Dolastatin 15 is rated 5.0 out of 5 by 1.
Aplicação Dolastatin 15 is an apoptotic agent through Blc-2 phosphorylation
Numero VAT: 123884-00-4
Privada: ≥98%
Peso Molecular: 837.06
Separar por Funcao: C45H68N6O9
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).

Dolastatin 15 is a member of the dolastatin family. Dolastatins are marine natural products isolated from the sea hare Dolabella auricularia with a structure related to Dolastin 10. Dolastatin 15 is an anti-neoplastic pseudopeptide that inhibits Tubulin-dependent GTP hydrolysis to Tubulin but has been shown to bind to the RZX/MAY region. The compound acts as a weak Tubulin inhibitor by binding to the vinca domain of tubulin and induces apoptosis through Bcl-2 phosphorylation in several malignant cell types. Potent inhibitor of the proliferation of murine and cancer cell lines as well as that of hematopoietic progenitor cells. When added to leukemia cultures Dolastin 15 inhibited both immunoglobulin production and cell proliferation.


  1. Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.  |  Cruz-Monserrate, Z., et al. 2003. Eur J Biochem. 270: 3822-8. PMID: 12950266
  2. Dolastatin 10 and dolastatin 15: effects of two natural peptides on growth and differentiation of leukemia cells.  |  Steube, KG., et al. 1992. Leukemia. 6: 1048-53. PMID: 1405759
  3. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.  |  Bai, R., et al. 1992. Biochem Pharmacol. 43: 2637-45. PMID: 1632820
  4. A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells.  |  Sato, M., et al. 2007. Int J Oncol. 30: 1453-9. PMID: 17487366
  5. Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity.  |  Bai, R., et al. 2009. Mol Pharmacol. 75: 218-26. PMID: 18927208
  6. Dolastatin 15, a mollusk linear peptide, and Celecoxib, a selective cyclooxygenase-2 inhibitor, prevent preneoplastic colonic lesions and induce apoptosis through inhibition of the regulatory transcription factor NF- kappa B and an inflammatory protein, iNOS.  |  Piplani, H., et al. 2012. Eur J Cancer Prev. 21: 511-22. PMID: 22441428
  7. Up-regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of COX-2 inhibitor, Celecoxib and Dolastatin 15, a marine mollusk linear peptide in experimental colon carcinogenesis.  |  Piplani, H., et al. 2013. Mol Carcinog. 52: 845-58. PMID: 22623379
  8. Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1 alpha Mediated Cancer Cell Viability and Vascularization.  |  Ratnayake, R., et al. 2020. Chembiochem. 21: 2356-2366. PMID: 32237262
  9. Phycochemistry and bioactivity of cyanobacterial secondary metabolites.  |  Srivastava, R., et al. 2022. Mol Biol Rep. 49: 11149-11167. PMID: 36161579
  10. The bcl-2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma.  |  Maki, A., et al. 1995. Anticancer Drugs. 6: 392-7. PMID: 7670136
  11. Growth inhibition of human lymphoma cell lines by the marine products, dolastatins 10 and 15.  |  Beckwith, M., et al. 1993. J Natl Cancer Inst. 85: 483-8. PMID: 8445676
  12. Effects of dolastatins on human B-lymphocytic leukemia cell lines.  |  Hu, ZB., et al. 1993. Leuk Res. 17: 333-9. PMID: 8487581
  13. Dolastatin 15 induces apoptosis and BCL-2 phosphorylation in small cell lung cancer cell lines.  |  Ali, MA., et al. 1998. Anticancer Res. 18: 1021-6. PMID: 9615758

Estado físico :
envie :
Soluble in DMSO, and methanol.
Manutencao :
Store at -20° C
Ponto de fervura :
954.01° C at 760 mmHg
Densidade :
1.21 g/cm3
Indice de produtos :
n20D 1.57
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
PubChem CID :
Numero de FAX :
CC(C)[[email protected]@H](C(=O)N(C)[[email protected]@H](C(C)C)C(=O)N1CCC[[email protected]]1C(=O)N2CCC[[email protected]]2C(=O)O[[email protected]@H](C(C)C)C(=O)N3[[email protected]](C(=CC3=O)OC)CC4=CC=CC=C4)NC(=O)[[email protected]](C(C)C)N(C)C

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Certificado de Análise

SAMPLE Certificate of Analysis (COA)

Catalog Number:sc-201449
Lot Number:SAMPLE
Product Name:Dolastatin 15
Molecular Formula:C45H68N6O9
Molecular Weight:837.06
Appearance (Color)White
Purity (HPLC)≥ 98%


Exp. Date: 6/18/2024

Dolastatin 15 (CAS 123884-00-4)  Citacoes dos Produtos

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Citações 1 para 4 de 4 total
Citações 1 para 4 de 4 total
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