Dolastatin 15 (CAS 123884-00-4)
Dolastatin 15 is a member of the dolastatin family. Dolastatins are marine natural products isolated from the sea hare Dolabella auricularia with a structure related to Dolastin 10. Dolastatin 15 is an anti-neoplastic pseudopeptide that inhibits Tubulin-dependent GTP hydrolysis to Tubulin but has been shown to bind to the RZX/MAY region. The compound acts as a weak Tubulin inhibitor by binding to the vinca domain of tubulin and induces apoptosis through Bcl-2 phosphorylation in several malignant cell types. Potent inhibitor of the proliferation of murine and cancer cell lines as well as that of hematopoietic progenitor cells. When added to leukemia cultures Dolastin 15 inhibited both immunoglobulin production and cell proliferation.
Referencias
- Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography. | Cruz-Monserrate, Z., et al. 2003. Eur J Biochem. 270: 3822-8. PMID: 12950266
- Dolastatin 10 and dolastatin 15: effects of two natural peptides on growth and differentiation of leukemia cells. | Steube, KG., et al. 1992. Leukemia. 6: 1048-53. PMID: 1405759
- Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules. | Bai, R., et al. 1992. Biochem Pharmacol. 43: 2637-45. PMID: 1632820
- A natural peptide, dolastatin 15, induces G2/M cell cycle arrest and apoptosis of human multiple myeloma cells. | Sato, M., et al. 2007. Int J Oncol. 30: 1453-9. PMID: 17487366
- Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity. | Bai, R., et al. 2009. Mol Pharmacol. 75: 218-26. PMID: 18927208
- Dolastatin 15, a mollusk linear peptide, and Celecoxib, a selective cyclooxygenase-2 inhibitor, prevent preneoplastic colonic lesions and induce apoptosis through inhibition of the regulatory transcription factor NF- kappa B and an inflammatory protein, iNOS. | Piplani, H., et al. 2012. Eur J Cancer Prev. 21: 511-22. PMID: 22441428
- Up-regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of COX-2 inhibitor, Celecoxib and Dolastatin 15, a marine mollusk linear peptide in experimental colon carcinogenesis. | Piplani, H., et al. 2013. Mol Carcinog. 52: 845-58. PMID: 22623379
- Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1 alpha Mediated Cancer Cell Viability and Vascularization. | Ratnayake, R., et al. 2020. Chembiochem. 21: 2356-2366. PMID: 32237262
- Phycochemistry and bioactivity of cyanobacterial secondary metabolites. | Srivastava, R., et al. 2022. Mol Biol Rep. 49: 11149-11167. PMID: 36161579
- The bcl-2 and p53 oncoproteins can be modulated by bryostatin 1 and dolastatins in human diffuse large cell lymphoma. | Maki, A., et al. 1995. Anticancer Drugs. 6: 392-7. PMID: 7670136
- Growth inhibition of human lymphoma cell lines by the marine products, dolastatins 10 and 15. | Beckwith, M., et al. 1993. J Natl Cancer Inst. 85: 483-8. PMID: 8445676
- Effects of dolastatins on human B-lymphocytic leukemia cell lines. | Hu, ZB., et al. 1993. Leuk Res. 17: 333-9. PMID: 8487581
- Dolastatin 15 induces apoptosis and BCL-2 phosphorylation in small cell lung cancer cell lines. | Ali, MA., et al. 1998. Anticancer Res. 18: 1021-6. PMID: 9615758
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SAMPLE Certificate of Analysis (COA)
Dolastatin 15 | CAS 123884-00-4 SAMPLE Certificate of AnalysisCertificado de Análise
SAMPLE Certificate of Analysis (COA)
| Test | Specification | Results |
|---|---|---|
| Appearance (Color) | White | |
| Purity (HPLC) | ≥ 98% |
TEST CONDITIONS
Exp. Date: 6/18/2024
Dolastatin 15 (CAS 123884-00-4) Citacoes dos Produtos
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PMID: 25633196 | Cell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1. | Cho, YC. et al. 2015. Cell Death Differ. 22: 1605-17.
PMID: 23872169 | Dolastatin, along with Celecoxib, stimulates apoptosis by a mechanism involving oxidative stress, membrane potential change and PI3-K/AKT pathway down regulation. | Piplani, H. et al. 2013. Biochimica et biophysica acta. 1830: 5142-56.
PMID: 22623379 | Up-regulation of p53 and mitochondrial signaling pathway in apoptosis by a combination of COX-2 inhibitor, Celecoxib and Dolastatin 15, a marine mollusk linear peptide in experimental colon carcinogenesis. | Piplani, H. et al. 2013. Mol. Carcinog. 52: 845-58.
PMID: 22441428 | Dolastatin 15, a mollusk linear peptide, and Celecoxib, a selective cyclooxygenase-2 inhibitor, prevent preneoplastic colonic lesions and induce apoptosis through inhibition of the regulatory transcription factor NF-κB and an inflammatory protein, iNOS. | Piplani, H. et al. 2012. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 21: 511-22.