BIN3 Anticorpo (4-RE18): sc-134282

BAR adaptor proteins primarily function to integrate signal transduction pathways that regulate nuclear processes, as well as the F-Actin cytoskeleton and overall membrane dynamics. BIN3 (Bridging integrator 3) is a 253 amino acid cytoplasmic protein that contains a BAR domain and is found to be expressed in all tissues except for brain. The BAR domain functions to influence transcriptional repression, to sense or induce membrane curvature at endocytic sites and to bind to small GTPases. The gene encoding BIN3 is localized to a cancer suppressing region that is frequently found to be deleted in non-Hodgkin's lymphomas and several epithelial tumors. The yeast homolog of BIN3 has found to be involved in vesicle trafficking, cell polarity, cytokinesis and F-Actin organization. There are 2 isoforms of BIN3 that exist as a result of alternative slicing events.