Apamin CAS: 24345-16-2
MF: C79H131N31O24S4
MW: 2027.34
A potent and highly selective inhibitor of the low conductance Ca2+-activated K+ channel.

Apamin (CAS 24345-16-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 127ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Apamin is rated 5.0 out of 5 by 1.
loading
5
1
4
0
3
0
2
0
1
0
Aplicação Apamin is a potent and highly selective inhibitor of the low conductance Ca2+-activated K+ channel
Numero VAT: 24345-16-2
Privada: ≥95%
Peso Molecular: 2027.34
Separar por Funcao: C79H131N31O24S4
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
loading

Apamin: Caution! Highly toxic. Handle with care. The smallest neurotoxin known. It is the only polypeptide neurotoxin that is known to pass the blood-brain barrier. Comprises about 2% by weight of the dried venom of the honey bee. It is a potent (1-10 nM) and highly selective inhibitor of the SK (low conductance Ca2+-activated K+ channel). Acts on the central nervous system. SK channel blockers such as apamin can have therapeutic applications, for example on the peripheral cells (e.g. the insulin releasing cells of the pancreas) and on the central nervous system where there is evidence for a role of SK channels in memory processes, both general and specifically hippocampal.


Referencias

1: N.A. Castle et al. Trends Neurosci. 1989 12 59 2: M. Hughes et al. Proc. Natl. Acad. Sci. USA 1982 79 1308 3: P.N. Strong Pharmacol. Therap. 1990 46 137

Aparência :
Powder
Estado físico :
Solid
Sequencia :
Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2
envie :
Soluble in acetic acid (5mg/ml) and slightly soluble in water (1mg/ml)
Manutencao :
Store at -20° C
Indice de produtos :
n20D 1.72 (Predicted)
IC50 :
apamin-sensitive SKCa channel: IC50 = 0.001 µM (guinea-pig hepatocytes); calcium activated potassium channel: IC50 = 8.6e-06 µM
Data ki :
[125I]apamin binding to calcium-activated potassium (SK) channel: Ki= 3.8 µM (rat cortex)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
RTECS :
CD6899900
PubChem CID :
Indice de produtos :
14: 725
Numero de FAX :
MFCD00167944
Numero de FAX :
246-182-7
SMILES :
C[[email protected]]1C(=O)N[[email protected]](C(=O)N[[email protected]](C(=O)N[[email protected]@H](CSSC[[email protected]]2C(=O)N[[email protected]](C(=O)N[[email protected]](C(=O)N3CCC[[email protected]]3C(=O)N[[email protected]](C(=O)N[[email protected]](C(=O)N[[email protected]](C(=O)N[[email protected]](C(=O)N[[email protected]@H](CSSC[[email protected]@H](C(=O)N[[email protected]](C(=O)N2)CC(=O)N)N)C(=O)N1)CC(C)C)C)[[email protected]@H](C)O)CCC(=O)O)C)CCCCN)C(=O)N[[email protected]@H](CCC(=O)N)C(=O)N[[email protected]@H](CCC(=O)N)C(=O)N[[email protected]@H](CC4=CN=CN4)C(=O)N)CCCNC(=N)N)CCCNC(=N)N

Baixar SDS (MSDS)

Certificado de Análise

É necessário o Adobe Acrobat Reader para visualizar corretamente,
imprimir e comentar os documentos PDF

Apamin (CAS 24345-16-2)  Citacoes dos Produtos

Visualizar com outras pessoas usaram Apamin (CAS 24345-16-2). Clique em PubMed para ver .

Citações 1 para 6 de 6 total

PMID: # 31904168  Luo, T.|Li, L.|Peng, Y.|Xie, R.|Yan, N.|Fan, H.|Zhang, Q.| et al. 2021. Biofactors. 47: 69-79.

PMID: # 30260688  Sung, TS.|Lu, H.|Sung, J.|Yeom, JH.|Perrino, BA.|Koh, SD.| et al. 2018. Am J Physiol Gastrointest Liver Physiol. 315: G921-G931.

PMID: # 28036359  Estep, CM. et al. 2016. PLoS ONE. 11: e0169044.

PMID: # 25641660  Sung, TS. et al. 2015. J. Physiol. (Lond.). 593: 1169-81.

PMID: # 32086857  FASEB J.

PMID: # 29055091  Acta Physiol (Oxf).

Citações 1 para 6 de 6 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 108ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 8ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;