Amphotericin B CAS: 1397-89-3
Amphotericin B is an antifungal and useful cell culture antibiotic.

Amphotericin B (CAS 1397-89-3)

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Nomes alternativos: Fungizone
Aplicação Amphotericin B is an antifungal and useful cell culture antibiotic
Numero VAT: 1397-89-3
Peso Molecular: 924.09
Separar por Funcao: C47H73NO17
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).
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Amphotericin B, Streptomyces sp. is a polyene antifungal antibiotic that forms channels in fungal membranes inducing non-specific loss of low molecular weight molecules to leak out. The compounds mechanism of action is to bind to sterols and disrupt the osmotic integrity of the fungal membrane. In addition to Amphotericin B′s antifungal activity it has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B, Streptomyces sp. was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D (sc-200906) sensitivity in drug resistant HELA cells in vitro.


Referencias

1. Medoff, J., et al. 1975. Cancer Res. 35: 2548-2552. PMID: 1149049
2. Presant, C.A., et al. 1984. Cancer Treat Rep. 68: 651-654. PMID: 6201270
3. Barth, C., et al. 1993. Biophys. J. 64: 92-97. PMID: 7679300
4. Charak, B.S., et al. 1994. Br. J. Haematol. 88: 693-698. PMID: 7529537
5. Sundar, S., et al. 2010. N. Engl. J. Med. 362: 504-512. PMID: 20147716

Paginas :
Store at 4°C for up to 2 weeks.
For long term storage, store at -20°C.
Estado físico :
Solid
Derivado de :
Streptomyces sp.
envie :
Soluble in DMSO (30-40 mg/ml), acidic water (pH 2) or basic water (pH 11) (~0.1 mg/ml), DMF (2-4 mg/ml), DMF + 1 M HCl (3:1) (60-80 mg/ml), and methanol (slightly). Insoluble in ether.
Manutencao :
Desiccate at -20° C
Ponto de fervura :
~1140.4° C at 760 mmHg (Predicted)
Densidade :
~1.3 g/cm3 (Predicted)
Indice de produtos :
n20D 1.61 (Predicted)
IC50 :
Trichophyton mentagrophytes: IC50 = 0.02 µg/ml (Trichophyton mentagrophytes); Leishmania donovani: IC50 = 0.06 µg/ml (Leishmania donovani); Candida albicans: EC5050 = 0.25 µg/ml (Candida albicans)
Valores de pK :
pKa: 5.5, 10.0, pKb: 8.12
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
WGK Alemanha :
3
RTECS :
BU2625000
PubChem CID :
Indice de produtos :
14: 585
Numero de FAX :
MFCD00877763
Numero de FAX :
215-742-2
Registro Beilstein :
78342

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Amphotericin B (CAS 1397-89-3)  Citacoes dos Produtos

Visualizar com outras pessoas usaram Amphotericin B (CAS 1397-89-3). Clique em PubMed para ver .

Citações 1 para 7 de 7 total

PMID: # 33937102  Jenull, S.|Tscherner, M.|Kashko, N.|Shivarathri, R.|Stoiber, A.|Chauhan, M.|Petryshyn, A.|Chauhan, N.|Kuchler, K.| et al. 2021. Front Cell Infect Microbiol. 11: 662563.

PMID: # 33271062  Najafov, A.|Luu, HS.|Mookhtiar, AK.|Mifflin, L.|Xia, HG.|Amin, PP.|Ordureau, A.|Wang, H.|Yuan, J.| et al. 2020. Mol Cell.

PMID: # 29390164  Kilinçel, Ö.|Çaliskan, E.|Sahin, I.|Öztürk, CE.|Kiliç, N.|Öksüz, S.| et al. 2019. Med Mycol. 57: 45-51.

PMID: # 30157175  Najafov, A. et al. 2018. PLoS Biol. 16: e2005756.

PMID: # 28685000  143-150.

PMID: # 31907385  J. Hum. Genet.

PMID: # 32723117  J Drug Target. 1-34.

Citações 1 para 7 de 7 total
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