3-Keto Valproic Acid Sodium Salt 3-Keto Valproic Acid Sodium Salt is a useful main metabolite of Valproic Acid.

3-Keto Valproic Acid Sodium Salt (CAS 1184991-15-8)

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Nomes alternativos: 3-keto-VPA; 3-oxo-2-propyl-pentanoic Acid Sodium Salt; 2-Propyl-3-oxopentanoic Acid Sodium Salt;
Aplicação 3-Keto Valproic Acid Sodium Salt is a useful main metabolite of Valproic Acid
Numero VAT: 1184991-15-8
Privada: ≥95%
Peso Molecular: 180.18
Separar por Funcao: C8H13NaO3
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
* Refere-se a Certificado de Análise para data especifica de lotes (incluindo-se o conteúdo de agua).

3-Keto Valproic Acid Sodium Salt is the sodium salt of the main metabolite of Valproic Acid. 3-Keto Valproic Acid is produced from Valproic Acid metabolism by β-oxidation and may be useful for monitoring the metabolism of Valproic Acid in vitro . The parent compound, Valproic Acid, is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Metabolites of Valproic Acid are also available as:
Valproic Acid (sc-213144)
Valproic Acid, Sodium Salt (sc-202378)
3-Hydroxy Valproic Acid (sc-209599)
4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) (sc-216870)
rac 5-Hydroxy Valproic Acid Sodium Salt (sc-208266)
Valproic Acid β-D-Glucuronide Allyl Ester (sc-220360)
Valproic Acid β-D-Glucuronide (sc-213145)

Labelled forms of Valproic Acid are available as:
Valproic Acid-d6 (sc-213146)
Valproic Acid-d6 β-D-Glucuronide (sc-220361)
rac 5-Hydroxy Valproic Acid-d7 Sodium Salt (sc-219789)


Referencias

1. Böhles, H., et al. 1982. Eur. J. Pediatr. 139: 185-186. PMID: 6819143

2. Burchell, B., et al. 1989. Dev Pharmacol Ther. 13: 70-77. PMID: 2515047

3. Bjorge, S.M. and Baillie, T.A. 1991. Drug Metab. Dispos. 19: 823-829. PMID: 1680661

4. Rettie, A.E., et al. 1995. Biochemistry. 34: 7889-7895. PMID: 7794900

5. Bello-Ramírez, A.M., et al. 2002. Epilepsia. 43: 475-481. PMID: 12027907

Estado físico :
Solid
Manutencao :
Store at -20° C
Ponto de fusão :
>250° C (dec.)
Para uso em exclusivo em pesquisa. Não se destina a uso em diagnostico e tratamento.
PubChem CID :
SMILES :
CCCC(C(=O)CC)C(=O)[O-].[Na+]

Baixar SDS (MSDS)

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