Zolmitriptan CAS: 139264-17-8
MF: C16H21N3O2
MW: 287.36
A serotonin 5HTID-receptor agonist.

Zolmitriptan (CAS 139264-17-8)

Zolmitriptan | CAS 139264-17-8 is rated 5.0 out of 5 by 1.
  • y_2021, m_7, d_26, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.18
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_220415, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 132ms
  • REVIEWS, PRODUCT
loading
5
1
4
0
3
0
2
0
1
0
Alternate Names: (4S)-4-[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl-2-oxazolidinone; BW-311C90; Zomig
Application: Zolmitriptan is a serotonin 5HTID-receptor agonist
CAS Number: 139264-17-8
Purity: ≥99%
Molecular Weight: 287.36
Molecular Formula: C16H21N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

Zolmitriptan is a Serotonin SR-1D (5HTID-receptor) agonist. Zolmitriptan is an activator of SR-1B.


References

Glen, R.C., et al.: J. Med. Chem., 38, 3566 (1995), Seaber, E., et al.: Brit. J. Clin. Pharmacol., 41, 141 (1996), Tepper, S.J., et al.: Curr. Med. Res. Opin., 15, 254 (1999)

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml), DMSO (58 mg/ml at 25° C), methanol, and ethanol (58 mg/ml).
Storage :
Store at 4° C
Melting Point :
135-137° C
Boiling Point :
~563.3° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α20/D -6.93°, c = 0.20 in methanol; α20/D °
IC50 :
SR-1B: EC5050 = 15.7 nM (human); Cardiovascular toxicity in human coronary arteries assessed as induction of vasoconstriction : EC5050 = 40 nM
Ki Data :
SR-1D: Ki= 0.76 nM (human); SR-1B: Ki= 4.2 nM (human); 5-HT1F: Ki= 63 nM; SR-1A: Ki= 78.6 nM (human)
pK Values :
pKa: 12.57 (Predicted), pKb: 9.52 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
RQ2707000
PubChem CID :
Merck Index :
14: 10189
MDL Number :
MFCD00871503
Beilstein Registry :
7415010
SMILES :
CN(C)CCC1=CNC2=C1C=C(C=C2)C[[email protected]]3COC(=O)N3

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 109ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Liu et al Liu et al. (PubMed ID 25771739) found that zolmitriptan trasdermal patches allowed for more effective delivery of drugs into systemic circulation without causing irritation in rabbit skin. -SCBT Publication Review
Date published: 2015-02-16
  • y_2021, m_7, d_26, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.18
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_220415, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 15ms
  • REVIEWS, PRODUCT