Zoledronic acid monohydrate, also known as cgp 42′446, is a heterocyclic bisphosphonate that is considered to have the highest potency of bisphosphonates for suppression of increased bone resorption and has been used in several osteoporosis studies. The compound has been observed to be more effective than pamidronate (sc-203178). Zoledronic acid has been used in studies investigating mesothelioma. Zoledronic acid monohydrate is an inhibitor of ASM and FDPS and an activator of PKC.
1. Green, J.R., et al. 1994. J. Bone Miner. Res. 9: 745-751. PMID: 8053405 2. Saad, F., et al. 2002. J. Natl. Cancer Inst. 94: 1458-1468. PMID: 12359855 3. Reid, I.R., et al. 2002. N. Engl. J. Med. 346: 653-661. PMID: 11870242 4. Black, D.M., et al. 2007. N. Engl. J. Med. 356: 1809-1822. PMID: 17476007 5. Veltman, J.D., et al. 2010. Br J Cancer. 103: 629-641. PMID: 20664588
Soluble in water (7 mg/ml), 0.1N NaOH, methanol (0.12 mg/ml at 25° C), and ethanol (0.13 mg/ml at 25° C).
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Dalle CarbonareDalle Carbonare, L. et al. (PubMed 26330244) used Zoledronic acid, potent bisphosphonate and activator of PKC, to interfere with the development of sickle bone disease in hypoxia/reperfusion exposed mice. Zoledronic acid significantly inhibited osteoclast activity and recruitment, promoting osteogenic lineage. -SCBT Publication Review
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