Zoledronic acid monohydrateA highly potent bisphosphonate and activator of PKC

Zoledronic acid monohydrate (CAS 165800-06-6)

Zoledronic acid monohydrate | CAS 165800-06-6 is rated 5.0 out of 5 by 1.
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Synonym: Zoledronic acid
Application: A highly potent bisphosphonate and activator of PKC
CAS Number: 165800-06-6
Purity: >98%
Molecular Weight: 290.1
Molecular Formula: C5H10N2O7P2•H2O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Zoledronic acid monohydrate, also known as cgp 42′446, is a heterocyclic bisphosphonate that is considered to have the highest potency of bisphosphonates for suppression of increased bone resorption and has been used in several osteoporosis studies. The compound has been observed to be more effective than pamidronate (sc-203178). Zoledronic acid has been used in studies investigating mesothelioma. Zoledronic acid monohydrate is an inhibitor of ASM and FDPS and an activator of PKC.


References

1. Green, J.R., et al. 1994. J. Bone Miner. Res. 9: 745-751. PMID: 8053405
2. Saad, F., et al. 2002. J. Natl. Cancer Inst. 94: 1458-1468. PMID: 12359855
3. Reid, I.R., et al. 2002. N. Engl. J. Med. 346: 653-661. PMID: 11870242
4. Black, D.M., et al. 2007. N. Engl. J. Med. 356: 1809-1822. PMID: 17476007
5. Veltman, J.D., et al. 2010. Br J Cancer. 103: 629-641. PMID: 20664588

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (7 mg/ml), 0.1N NaOH, methanol (0.12 mg/ml at 25° C), and ethanol (0.13 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
238.9° C (dec.)
Boiling Point :
764° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
FDPS: IC50 = 3 nM (human); Osteoclastogenesis: IC50 = 15 nM; Farnesyl pyrophosphate synthase: IC50 = 110 nM (Leishmania donovani); aSMase: IC50 = 5 µM; Proliferation of foetal osteoblastic cell line (hFOB): IC50 = 40 µM (human)
Ki Data :
FDPS: Ki= 0.07 nM (human); Farnesyl pyrophosphate synthase: Ki= 11 nM (Leishmania donovani); Geranylgeranyl pyrophosphate synthase: Ki= 260 nM (Saccharomyces cerevisiae S288c); GGPS1: Ki= 2.7 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
121586
Merck Index :
14: 10187
MDL Number :
MFCD08448695
SMILES :
C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O.O

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Certificate of Analysis

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Zoledronic acid monohydrate  Product Citations

See how others have used Zoledronic acid monohydrate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28941405  Zenobi, W. et al. 2018. J Mech Behav Biomed Mater. 77: 199-204.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Dalle Carbonare Dalle Carbonare, L. et al. (PubMed 26330244) used Zoledronic acid, potent bisphosphonate and activator of PKC, to interfere with the development of sickle bone disease in hypoxia/reperfusion exposed mice. Zoledronic acid significantly inhibited osteoclast activity and recruitment, promoting osteogenic lineage. -SCBT Publication Review
Date published: 2015-03-27
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