Zoledronic acid, anhydrousA protein kinase C activator with apoptotic effects

Zoledronic acid, anhydrous (CAS 118072-93-8)

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Synonym: Zoledronate
Application: A protein kinase C activator with apoptotic effects
CAS Number: 118072-93-8
Purity: ≥98%
Molecular Weight: 272.09
Molecular Formula: C5H10N2O7P2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Zoledronic acid, one of the most potent nitrogen-containing bisphosphonates, induces anti-proliferative and apoptotic effects on multiple myeloma cell lines in vitro by activating protein kinase C. Zoledronic acid also inhibits proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 μM. In cultures of freshly isolated rabbit and human osteoclasts zoledronic acid (10-100 μM) induced morphological features similar to apoptosis and Osteoclastogenesis was inhibited with an IC50 of 15 nM.

Physical State :
Solid
Solubility :
Soluble in DMSO (0.004 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Storage :
Store at -20° C
IC50 :
Morphological features similar to apoptosis and Osteoclastogenesis: IC50 = 15 nM (cultures of freshly isolated rabbit and human osteoclasts ); Proliferation of human foetal osteoblastic cell: IC50 = 40 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
68740
MDL Number :
MFCD00867791
SMILES :
C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O

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Certificate of Analysis

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