Molecular structure of Zofenoprilat Sodium Salt, CAS Number: 1329569-13-2
Zofenoprilat Sodium Salt (CAS 1329569-13-2)
Alternate Names:
(4S)-1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline Sodium
Application:
Zofenoprilat Sodium Salt is an active free sulfhydryl compound of Zenopril
CAS Number:
1329569-13-2
Molecular Weight:
347.43
Molecular Formula:
C15H18NO3S2•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Zofenoprilat is the active free sulfhydryl compound of Zenopril. Zenopril is an antioxidant that acts as an ACE (angiotensin-converting enzyme) inhibitor. Endothelial membrane studies have demonstrated that Zofenoprilat induces the bradykinin B1 receptors, which activates the expression of FGF-2. Studies show that Zofenoprilat is more effective than Enalaprilat (sc-205669) at protecting pancreatic islets from extended high glucose exposure. We provide the Zofenoprilat Sodium Salt form.
Zofenoprilat Sodium Salt (CAS 1329569-13-2) References
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- Cardioprotective effect of zofenopril in perfused rat heart subjected to ischemia and reperfusion. | Frascarelli, S., et al. 2004. J Cardiovasc Pharmacol. 43: 294-9. PMID: 14716220
- Relative lipophilicities and structural-pharmacological considerations of various angiotensin-converting enzyme (ACE) inhibitors. | Ranadive, SA., et al. 1992. Pharm Res. 9: 1480-6. PMID: 1475237
- A review of the angiotensin-converting enzyme inhibitor, zofenopril, in the treatment of cardiovascular diseases. | Borghi, C., et al. 2004. Expert Opin Pharmacother. 5: 1965-77. PMID: 15330734
- Zofenoprilat-glutathione mixed disulfide as a specific S-thiolating agent of bovine lens aldose reductase. | Dal Monte, M., et al. 2005. Antioxid Redox Signal. 7: 841-8. PMID: 15998238
- The direct effects of the angiotensin-converting enzyme inhibitors, zofenoprilat and enalaprilat, on isolated human pancreatic islets. | Lupi, R., et al. 2006. Eur J Endocrinol. 154: 355-61. PMID: 16452552
- Fibroblast growth factor-2 mediates Angiotensin-converting enzyme inhibitor-induced angiogenesis in coronary endothelium. | Donnini, S., et al. 2006. J Pharmacol Exp Ther. 319: 515-22. PMID: 16868034
- Coronary vasodilation induced by captopril and zofenoprilat: evidence for a prostaglandin-independent mechanism. | van Wijngaarden, J., et al. 1991. Naunyn Schmiedebergs Arch Pharmacol. 343: 491-5. PMID: 1881459
- Effects of zofenopril and ramipril on cough reflex responses in anesthetized and awake rabbits. | Mutolo, D., et al. 2010. J Cardiovasc Pharmacol Ther. 15: 384-92. PMID: 20924096
- Angiotensin-converting-enzyme inhibition counteracts angiotensin II-mediated endothelial cell dysfunction by modulating the p38/SirT1 axis. | Marampon, F., et al. 2013. J Hypertens. 31: 1972-83. PMID: 23868084
- The sulphydryl containing ACE inhibitor Zofenoprilat protects coronary endothelium from Doxorubicin-induced apoptosis. | Monti, M., et al. 2013. Pharmacol Res. 76: 171-81. PMID: 23965518
- Comparisons in vitro, ex vivo, and in vivo of the actions of seven structurally diverse inhibitors of angiotensin converting enzyme (ACE). | Cushman, DW., et al. 1989. Br J Clin Pharmacol. 28 Suppl 2: 115S-130S; discussion 130S-131S. PMID: 2557876
- The haemodynamic effects of two angiotensin converting enzyme inhibitors, enalaprilat and zofenoprilat, in the rat: evidence for the involvement of bradykinin. | Tio, RA., et al. 1989. J Hypertens Suppl. 7: S296-7. PMID: 2561143
- Characterization of zofenoprilat as an inducer of functional angiogenesis through increased H2 S availability. | Terzuoli, E., et al. 2015. Br J Pharmacol. 172: 2961-73. PMID: 25631232
- Site-specific inactivation of aldose reductase by 4-hydroxynonenal. | Del Corso, A., et al. 1998. Arch Biochem Biophys. 350: 245-8. PMID: 9473298
Inhibitor of:
ACE.Activator of:
bradykinin B1 R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zofenoprilat Sodium Salt, 1 mg | sc-220411 | 1 mg | $374.00 |