Zofenoprilat Sodium SaltAn active free sulfhydryl compound of Zenopril

Zofenoprilat Sodium Salt (CAS 75176-37-3 (free base))

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Synonym: (4S)-1-[(2S)-3-Mercapto-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline Sodium
Application: An active free sulfhydryl compound of Zenopril
CAS Number: 75176-37-3 (free base)
Molecular Weight: 347.43
Molecular Formula: C15H18NO3S2•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Zofenoprilat is the active free sulfhydryl compound of Zenopril. Zenopril is an antioxidant that acts as an angiotensin-converting enzyme inhibitor. Endothelial membrane studies have demonstrated that Zofenoprilat induces the bradykinin B1 receptors, which activates the expression of FGF-2. Studies show that Zofenoprilat is more effective than Enalaprilat (sc-205669) at protecting pancreatic islets from extended high glucose exposure. We provide the Zofenoprilat Sodium Salt form.


References

1. Cushman, D.W., et al. 1989. Br J Clin Pharmacol. 28S: 115S-130S. PMID: 2557876
2. Borghi, C., et al. 2004. Expert Opin Pharmacother. 5: 1965-1977. PMID: 15330734
3. Lupi, R., et al. 2006. Eur. J. Endocrinol. 154: 355-361. PMID: 16452552
4. Donnini, S., et al. 2006. J. Pharmacol. Exp. Ther. 319: 515-522. PMID: 16868034

Physical State :
Solid
Solubility :
Soluble in DMSO, water, and methanol.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
57347771
SMILES :
C[C@H](CS)C(=O)N1C[C@H](C[C@H]1C(=O)[O-])SC2=CC=CC=C2.[Na+]

Download SDS (MSDS)

Certificate of Analysis

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