ZM 336372 CAS: 208260-29-1
MF: C23H23N3O3
MW: 389.45
A potent and selective Raf-1 inhibitor.

ZM 336372 (CAS 208260-29-1)

ZM 336372 | CAS 208260-29-1 is rated 5.0 out of 5 by 1.
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Alternate Names: 3-(Dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide
Application: ZM 336372 is a potent and selective Raf-1 inhibitor
CAS Number: 208260-29-1
Purity: ≥95%
Molecular Weight: 389.45
Molecular Formula: C23H23N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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ZM 336372 is a reversible, selective inhibitor of the protein kinase Raf-1 (IC50 = 70nM). Although ZM 336372 weakly inhibits Raf-B, it is 10 fold more potent against Raf-1 and so is considered more selective towards this kinase. ZM 336372 inhibits Raf-1 by competing with ATP to bind to the protein. Alternate studies suggest that ZM 336372 can induce apoptosis in pancreatic adenocarcinoma cell lines by inhibiting glycogen synthase kinase-3β (GSK-3β) through phosphorylation of GSK-3&beta at Ser 9. In addition, ZM 336372 can suppress the proliferation of hepatocellular carcinoma cells by inhibiting hormone secretion and up-regulating cell cycle inhibitors. Furthermore, ZM 336372 can also act as an agonist towards Raf-1, activating the MAPK pathway, which can be suppressed after activation by Raf-1 itself, using a novel feedback loop in which activation is always followed by inactivation. ZM 336372 is an inhibitor of p38 α and p38 β.


References

1. Hall-Jackson, C.A., et al. 1999. Chem. Biol. 6: 559-568. PMID: 10421767
2. Deming, D., et al. 2008. J. Gastrointest. Surg. 12: 852-857. PMID: 18299943
3. Deming, D., et al. 2010. J. Surg. Res. 161: 28-32. PMID: 20031160

Physical State :
Solid
Solubility :
Soluble in DMSO (200 mg/ml), DMF (~20 mg/ml), water (0.5 mg/ml at 25° C), and ethanol (2 mg/ml at 25° C).
Storage :
Store at -20° C
Melting Point :
283.32° C (Predicted)
Boiling Point :
~484.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
c-Raf : IC50 = 70 nM; p38α: IC50 = 2 µM; p38β: IC50 = 2 µM
pK Values :
pKa: 8.31 (Predicted), pKb: 3.83 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD02683971
SMILES :
CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)N(C)C)NC(=O)C3=CC=C(C=C3)O

Download SDS (MSDS)

Certificate of Analysis

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ZM 336372 (CAS 208260-29-1)  Product Citations

See how others have used ZM 336372 (CAS 208260-29-1). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 11714782  Chuang, SS. et al. 2001. J. Immunol. 167: 6210-6216.

PMID: # 26649302  Biomed Res Int. 414250.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Chuang Chuang, SS. et al. (PubMed 11714782) used ZM 336372, a potent and selective Raf-1 inhibitor, to demonstrate that 2B4 stimulation of NK cells is dependent on Ras and Raf. -SCBT Publication Review
Date published: 2015-07-16
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