ZK 93423 hydrochloride is a potent benzodiazepine agonist. Non-selective with GABAA receptors containing α1-, α2-, α3- and α5-subunits.
Stephens et al (1984) Discriminative stimulus properties of b-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors. Psychopharmacology 83 233. File and Baldwin (1987) Effects of b-carbolines in animal models of anxiety. Brain Res.Bull. 19 293. Cox et al (1998) Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-b-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-b-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors. J.Med.Chem. 41 2537.