Zinc Protoporphyrin-9An inhibitor of heme oxygenase, GCS, NOS1, NOS2, and NOS3

Zinc Protoporphyrin-9 (CAS 15442-64-5)

Zinc Protoporphyrin-9 | CAS 15442-64-5 is rated 5.0 out of 5 by 1.
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Synonym: ZINC Protoporphyrin IX
Application: An inhibitor of heme oxygenase, GCS, NOS1, NOS2, and NOS3
CAS Number: 15442-64-5
Molecular Weight: 626.05
Molecular Formula: C34H32N4O4Zn
* Refer to Certificate of Analysis for lot specific data (including water content).
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Zinc protoporphyrin-9 is a potent, selective heme oxygenase inhibitor, interleukin-1 antagonist, GCS inhibitor, and NOS1, NOS2, and NOS3 inhibitor. Heme oxygenase catalyzes heme degradation to produce CO, which is an activator of guanylyl cyclase and shares some chemical and biological properties of NO. Zinc protoporphyrin-9 exhibits a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8μM, 4.0μM, and 5.0μM for NOS1, NOS2 and NOS3, respectively). In olfactory neuronal cultures, this product has been used to block CO biosynthesis, which lowered cGMP concentrations. Zinc protoporphyrin-9 is an extremely useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter. Copper(II) Protoporphyrin IX (free acid) (sc-205935) can be used as a negative control in heme oxygenase studies.


References

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Physical State :
Solid
Solubility :
Soluble in ethanol (10 mg/ml), and DMSO (20 mg/ml)pyridine, or dimethyl formamide. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures.. Insoluble in water.
Storage :
Store at -20° C
IC50 :
nNOS: IC50 = 0.8 µM; iNOS: IC50 = 4.0 µM; eNOS: IC50 = 5.0 µM
Ki Data :
Heme oxygenase: Ki= 3 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
ZG9210300
PubChem CID :
455799
MDL Number :
MFCD00011612
EC Number :
239-455-7
SMILES :
CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C)CCC(=O)O)CCC(=O)O.[Zn+2]

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Zinc Protoporphyrin-9  Product Citations

See how others have used Zinc Protoporphyrin-9. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 13 total

PMID: # 30653942  2019. Transl Res. 207: 56-69.

PMID: # 31076999  Jin, Y.|Wang, H.| et al. 2019. Neurotox Res.

PMID: # 28808929  Zhao, Z. et al. 2017. Clin Transl Oncol.

PMID: # 27006498  Burton, MJ.|Kapetanaki, SM.|Chernova, T.|Jamieson, AG.|Dorlet, P.|Santolini, J.|Moody, PC.|Mitcheson, JS.|Davies, NW.|Schmid, R.|Raven, EL.|Storey, NM.| et al. 2016. Proc. Natl. Acad. Sci. U.S.A. 113: 3785-90.

PMID: # 26286380  Tang, J. et al. 2015. Scand. J. Immunol. 82: 443-51.

PMID: # 24755677  Ni, H. et al. 2014. PLoS ONE. 9: e95846.

PMID: # 22147269  Wang, HQ. et al. 2012. Neurotox Res. 21: 368-78.

PMID: # 20828541  Wang, HQ. et al. 2010. Brain Res. 1360: 159-67.

PMID: # 16181424  Moon, C. et al. 2005. J. Neurochem. 95: 200-209.

PMID: # 8608001  Ingi, T. et al. 1996. Neuron. 16: 835-842.

Citations 1 to 10 of 13 total
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Rated 5 out of 5 by from Ingi et al Ingi et al. (PubMed ID 8608001) used zinc protoporphyrin-9 (ZnPP-9) to inhibit heme oxygengase (HO) activity, which lowered 14CO release. -SCBT Publication Review
Date published: 2015-05-27
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