ZardaverineA pyridazinone derivative and a selective inhibitor of phosphodiesterase type III and IV

Zardaverine (CAS 101975-10-4)

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Application: A pyridazinone derivative and a selective inhibitor of phosphodiesterase type III and IV
CAS Number: 101975-10-4
Purity: ≥98%
Molecular Weight: 268.2
Molecular Formula: C12H10F2N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Zardaverine is a pyridazinone derivative and a selective and dual inhibitor of PDE3 and PDE4. Zardaverine is a potent bronchiodilator in vitro. This compound has been shown to inhibit inflammatory cell function and exert a positive inotropic action on heart muscle.


References

1. Schudt, C., et al. 1991. Biochem. Pharmacol. 42: 1153-162. PMID: 1648920
2. Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270: 250-259. PMID: 8035322

Physical State :
Solid
Solubility :
Soluble in DMSO (25mg/ml)
Storage :
Store at room temperature
Melting Point :
185.67° C (Predicted)
Boiling Point :
442.35° C (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
PDE IV: IC50 = 1.1 µM; PDE III: IC50 = 2.5 µM; Phosphodiesterase 3B: IC50 = 0.11 µM (human); Phosphodiesterase 4C: IC50 = 0.21 µM (Rattus norvegicus); Phosphodiesterase 4D: IC50 = 0.39 µM (human)
pK Values :
pKa: 10.89
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UR6326000
PubChem CID :
5723
MDL Number :
MFCD00867059
SMILES :
COC1=C(C=CC(=C1)C2=NNC(=O)C=C2)OC(F)F

Download SDS (MSDS)

Certificate of Analysis

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