Zamifenacin fumarate CAS: 127308-98-9
MF: C27H29NO3•C4H4O4
MW: 531.60
A selective antagonist of mAChR M3 (M3 muscarinic receptor).

Zamifenacin fumarate (CAS 127308-98-9)

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Alternate Names: (3R)-1-[2-(1-,3-Benzodioxol-5-yl)ethyl]-3-(diphenylmethoxy)piperidine fumarate
Application: Zamifenacin fumarate is a selective antagonist of mAChR M3 (M3 muscarinic receptor)
CAS Number: 127308-98-9
Molecular Weight: 531.60
Molecular Formula: C27H29NO3•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Zamifenacin fumarate is a selective antagonist of mAChR M3 (pKi values are 8.52, 7.93, 7.90 and 7.78 for mAChR M3, mAChR M2, mAChR M1 and mAChR M4 receptors, respectively). It displays higher affinity at ileal mAChR M3 (pKi = 9.3) compared to oesophageal and tracheal mAChR M3 receptors (pKi values are 8.8 and 8.2, respectively).


References

Wallis (1995) Pre-clinical and clinical pharmacology of selective muscarinic M3 receptor antagonists. Life Sci. 56 861. Watson et al (1995) Characterization of the interaction of zamifenacin at muscarinic receptors in vitro. Eur.J.Pharmacol. 285 135. Choppin (2002) Muscarinic receptors in isolated urinary bladder smooth muscle from different mouse strains. Br.J.Pharmacol. 137 522.

Physical State :
Solid
Solubility :
Soluble in ethanol (25 mM), and DMSO (100 mM).
Storage :
Desiccate at 4° C
Boiling Point :
700.2° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.63 (Predicted)
Optical Activity :
α20/D +198.5°, c = 5.34 in ethanol; α25/D +24°, c = 1.2 in ethanol
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD09263617
SMILES :
C1C[[email protected]](CN(C1)CCC2=CC3=C(C=C2)OCO3)OC(C4=CC=CC=C4)C5=CC=CC=C5.C(=C/C(=O)O)\\C(=O)O

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Certificate of Analysis

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