Zacopride hydrochlorideA highly potent SR-3 antagonist and SR-4 agonist

Zacopride hydrochloride (CAS 101303-98-4)

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Synonym: (±)-4-Amino-N-1-azabicyclo[2.2.2]oct -3-yl-5-chloro-2-methoxybenzamide hydrochloride
Application: A highly potent SR-3 antagonist and SR-4 agonist
CAS Number: 101303-98-4
Purity: ≥98%
Molecular Weight: 346.25
Molecular Formula: C15H20ClN3O2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Zacopride hydrochloride is a highly potent SR-3 antagonist (Ki = 0.38 nM) and SR-4 agonist (Ki = 373 nM). Zacopride hydrochloride is anti-emetic and anxiolytic following systemic administration in vivo.


References

1. Costall, B., et al. 1988. J. Pharm. Pharmacol. 40: 302-305. PMID: 2900320
2. Cohen, P. 1989. Annu. Rev. Biochem. 58: 453-508. PMID: 2549856
3. Kii, Y. and Ito, T. 1997. J. Cardiovasc. Pharmacol. 29: 670-675. PMID: 9213211
4. Nagakura, Y., et al. 1999. Pharmacol. Res. 39: 375-382. PMID: 10328995

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble to 100 mM in Water and to 100 mM in DMSO, to 100 mM in PBS, and to 75 mM in Ethanol
Storage :
Desiccate at room temperature
Ki Data :
5-HT3 receptor : Ki= 0.38 nM; 5-HT4 receptor : Ki= 373 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
CU8999100
PubChem CID :
9928181
SMILES :
COC1=CC(=C(C=C1C(=O)NC2CN3CCC2CC3)Cl)N.Cl

Download SDS (MSDS)

Certificate of Analysis

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Hello. Zacopride Hydrochloride (anhydrous) appears to have two CAS numbers, both 90182-92-6 (your website) and 101303-98-4 (Sigma-Aldrich). Also, can you provide the melt point or refractory index dissolved in water? I must ensure no mix up. Thanks

Asked by: Independent Scientist
Thank you for your question. We have confirmed that the CAS number currently shown on our website for this product, Zacopride hydrochloride (CAS 90182-92-6), is incorrect. The correct CAS number is 101303-98-4. We will update our product information to reflect the correct CAS number shortly. Unfortunately we are unable to provide the melting point and refractory index for this product in water.
Answered by: Technical Support
Date published: 2017-01-25
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