Z-L-Abu-CONH(CH2)3-morpholine is a cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of Calpain 1 and Calpain 2 (Ki = 140 nM and 41 nM, respectively). A weak inhibitor of cathepsin B (Ki = 6.9 μM). Has been shown to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.
Soluble in DMSO (5 mg/ml).
Store at 4° C
1.15 g/cm3 (Predicted)
n20D 1.52 (Predicted)
calpain-m-mediated degradation of neurofilament protein: IC50 = 600 nM
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