Z-L-Abu-CONH(CH2)3-morpholineA selective, reversible inhibitor of calpain-1 and calpain-2

Z-L-Abu-CONH(CH2)3-morpholine (CAS 145731-49-3)

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Synonym: Calpain Inhibitor XI
Application: A selective, reversible inhibitor of calpain-1 and calpain-2
CAS Number: 145731-49-3
Molecular Weight: 504.62
Molecular Formula: C26H40N4O6
* Refer to Certificate of Analysis for lot specific data (including water content).
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Z-L-Abu-CONH(CH2)3-morpholine is a cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of Calpain 1 and Calpain 2 (Ki = 140 nM and 41 nM, respectively). A weak inhibitor of cathepsin B (Ki = 6.9 μM). Has been shown to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at 4° C
Density :
1.15 g/cm3 (Predicted)
Refractive Index :
n20D 1.52 (Predicted)
IC50 :
calpain-m-mediated degradation of neurofilament protein: IC50 = 600 nM
Ki Data :
Calpain-1: Ki= 140 nM; Calpain-2: Ki= 41 nM; Cathepsin B: Ki= 6.9 µM
pK Values :
pKa: 11.1 (Predicted), pKb: 7.07 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9827472
SMILES :
CCC(C(=O)C(=O)NCCCN1CCOCC1)NC(=O)C(CC(C)C)NC(=O)OCC2=CC=CC=C2

Download SDS (MSDS)

Certificate of Analysis

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