Z-DEVD-pNA
Alternate Names:
Caspase-3 substrate (chromogenic)
Application:
Z-DEVD-pNA is a caspase-3 chromogenic substrate with increased cell permeability
Purity:
≥99%
Molecular Weight:
730.7
Molecular Formula:
C32H38N6O14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Z-DEVD-pNA is a caspase-3 chromogenic substrate with increased cell permeability. It is also a substrate for caspase-1,caspase-4 and caspase-7. λmax of pNA is 400nm. Z-DEVD-pNA is similar to Ac-DEVD-pNA except the N-terminus is blocked by a benzyloxycarbonyl (Z) moiety which may increase cell permeability.
References
1. Lazebnik, Y.A., et al. 1994. Nature. 371: 346-347. PMID: 8090205
2. Nicholson, D.W., et al. 1995. Nature 376: 37-43. PMID: 7596430
3. Thornberry, N.A. 1994. Meth. Enzymol. 244: 615-63. PMID: 7845238
4. Datta, R., et al. 1997. J. Biol. Chem. 272: 1965-1969. PMID: 8999887
Appearance
:
Lyophilized powder
Physical State
:
Solid
Sequence
:
Z-Asp-Glu-Val-Asp-pNa (pNA = p-Nitroaniline)
Solubility
:
Soluble in DMSO, and acetonitrile.
Storage
:
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Download SDS (MSDS)
Certificate of Analysis
Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents