Z-DEVD-pNAA caspase-3 chromogenic substrate with increased cell permeability

Z-DEVD-pNA

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Synonym: Caspase-3 substrate (chromogenic)
Application: A caspase-3 chromogenic substrate with increased cell permeability
Purity: ≥99%
Molecular Weight: 730.7
Molecular Formula: C32H38N6O14
* Refer to Certificate of Analysis for lot specific data (including water content).
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Z-DEVD-pNA is a caspase-3 chromogenic substrate with increased cell permeability. It is also a substrate for caspase-1,caspase-4 and caspase-7. λmax of pNA is 400nm. Z-DEVD-pNA is similar to Ac-DEVD-pNA except the N-terminus is blocked by a benzyloxycarbonyl (Z) moiety which may increase cell permeability.


References

1. Lazebnik, Y.A., et al. 1994. Nature. 371: 346-347. PMID: 8090205
2. Nicholson, D.W., et al. 1995. Nature 376: 37-43. PMID: 7596430
3. Thornberry, N.A. 1994. Meth. Enzymol. 244: 615-63. PMID: 7845238
4. Datta, R., et al. 1997. J. Biol. Chem. 272: 1965-1969. PMID: 8999887

Appearance :
Lyophilized powder
Physical State :
Solid
Sequence :
Z-Asp-Glu-Val-Asp-pNa (pNA = p-Nitroaniline)
Solubility :
Soluble in DMSO, and acetonitrile.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

Certificate of Analysis

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