Z-DEVD-FMK | CAS 210344-95-9 | SCBT - Santa Cruz Biotechnology
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Z-DEVD-FMK Z-DEVD-FMK is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10.
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Z-DEVD-FMK (CAS 210344-95-9)

Z-DEVD-FMK | CAS 210344-95-9 is rated 5.0 out of 5 by 1.
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See product citations (58)
Alternate Names: Z-DEVD-FMK is also known as Caspase-3 Inhibitor.
Application: Z-DEVD-FMK is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS Number: 210344-95-9
Purity: ≥98%
Molecular Weight: 668.66
Molecular Formula: C30H41N4O12F
* Refer to Certificate of Analysis for lot specific data (including water content).

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Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of Caspase-3/CPP32. Z-DEVD-FMK is also an irreversible inhibitor of Caspase-6, Caspase-7, caspase-8, and Caspase-10. Z-DEVD-FMK has been shown to inhibit tumor cell apoptosis.


References

1. Brockstedt, E., et al., 1998. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. The Journal of biological chemistry. 273(43): 28057-64. PMID: 9774422

2. Henshall, D C., et al., 2000. Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. Journal of neurochemistry. 74(3): 1215-23. PMID: 10693954

3. Kugawa, F., et al., 2000. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biological & pharmaceutical bulletin. 23(8): 930-5. PMID: 10963298

4. Chen, X. et al. 2015. Brain Res. 1625 : 275-286. PMID: 26367448

Usage :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month.
Physical State :
Solid
Sequence :
Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Solubility :
Soluble in DMSO (20 mM), and DMF.
Storage :
Store at -20° C
Boiling Point :
~914.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
caspase-3 : IC50 = 130 nM
WGK Germany :
3
PubChem CID :
16760394
MDL Number :
MFCD23380217
SMILES :
CC(C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](CCC(=O)OC)NC(=O)[[email protected]](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

SAMPLE Certificate of Analysis (COA)

Z-DEVD-FMK | CAS 210344-95-9  SAMPLE Certificate of Analysis

Certificate of Analysis

SAMPLE Certificate of Analysis (COA)

Catalog Number:sc-311558
Lot Number:SAMPLE
Product Name:Z-DEVD-FMK
Molecular Formula:C30H41N4O12F
Molecular Weight:668.66
TestSpecificationResults
AppearanceSolid
Purity≥ 98%

Z-DEVD-FMK (CAS 210344-95-9)  Product Citations

See how others have used Z-DEVD-FMK (CAS 210344-95-9). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 58 total

PMID: 36852999 | MLKL-Driven Inflammasome Activation and Caspase-8 Mediate Inflammatory Cell Death in Influenza A Virus Infection. | Lei, X. et al. 2023. mBio. e0011023.

PMID: 35286626 | CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1. | Tan, WH. et al. 2022. J Physiol Biochem. 78: 653-666.

PMID: 34975311 | Cell death mechanisms induced by synergistic effects of halofuginone and artemisinin in colorectal cancer cells. | Gong, RH. et al. 2022. Int J Med Sci. 19: 175-185.

PMID: 33618169 | Genotoxic effects of 1-nitropyrene in macrophages are mediated through a p53-dependent pathway involving cytochrome c release, caspase activation, and PARP-1 cleavage. | Wu, SW. et al. 2021. Ecotoxicol Environ Saf. 213: 112062.

PMID: 34607339 | Luteolin attenuates hepatic injury in septic mice by regulating P2X7R-based HMGB1 release. | Zhang, ZH. et al. 2021. Food Funct.

PMID: 30904799 | Combined Administration of Poly-ADP-Ribose Polymerase-1 and Caspase-3 Inhibitors Alleviates Neuronal Apoptosis After Spinal Cord Injury in Rats. | Zhao, W. et al. 2019. World Neurosurg. 127: e346-e352.

PMID: 30128650 | Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells. | Ali, F. et al. 2019. Mol. Neurobiol. 56: 3404-3419.

PMID: 31189945 | Cancer cell killing by target antigen engagement with engineered complementary intracellular antibody single domains fused to pro-caspase3. | Chambers, JS. et al. 2019. Sci Rep. 9: 8553.

PMID: 30795621 | The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells. | Nováková, J. et al. 2019. Cells. 8:

PMID: 30692621 | SERPINB1-mediated checkpoint of inflammatory caspase activation. | Choi, YJ. et al. 2019. Nat. Immunol. 20: 276-287.

Citations 1 to 10 of 58 total

What is the solubility of this compound?

Asked by: two2igm05
Thank you for your question. This chemical, Z-DEVD-FMK: sc-311558, is soluble in DMSO and DMF at ≥20mM.
Answered by: Chemical Support 2
Date published: 2017-02-24

Can this product be used in HPLC analysis?

Asked by: SCchem16
Thank you for your question. This chemical, Z-DEVD-FMK (CAS 210344-95-9), is suitable to be analyzed by HPLC.
Answered by: Chemical Support 2
Date published: 2017-02-24
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Rated 5 out of 5 by from Chen Chen, X. et al. (PubMed 26367448) used Z-DEVD-FMK, an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10, to demonstrate the involvment of caspase-3/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells. -SCBT Publication Review
Date published: 2015-02-17
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