Sorry, it seems JavaScript is not enabled in your browser. Please enable it to get the best site experience.

Z-DEVD-FMK | CAS 210344-95-9 | SCBT - Santa Cruz Biotechnology
Z-DEVD-FMK Z-DEVD-FMK is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10.

Z-DEVD-FMK (CAS 210344-95-9)

Z-DEVD-FMK | CAS 210344-95-9 is rated 5.0 out of 5 by 1.
  • y_2023, m_2, d_4, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.34
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_311558, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 103ms
  • REVIEWS, PRODUCT
loading
5
1
4
0
3
0
2
0
1
0
Alternate Names: Z-DEVD-FMK is also known as Caspase-3 Inhibitor.
Application: Z-DEVD-FMK is an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10
CAS Number: 210344-95-9
Purity: ≥98%
Molecular Weight: 668.66
Molecular Formula: C30H41N4O12F
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of Caspase-3/CPP32. Z-DEVD-FMK is also an irreversible inhibitor of Caspase-6, Caspase-7, caspase-8, and Caspase-10. Z-DEVD-FMK has been shown to inhibit tumor cell apoptosis.


References

1. Brockstedt, E., et al., 1998. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. The Journal of biological chemistry. 273(43): 28057-64. PMID: 9774422

2. Henshall, D C., et al., 2000. Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. Journal of neurochemistry. 74(3): 1215-23. PMID: 10693954

3. Kugawa, F., et al., 2000. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biological & pharmaceutical bulletin. 23(8): 930-5. PMID: 10963298

4. Chen, X. et al. 2015. Brain Res. 1625 : 275-286. PMID: 26367448

Usage :
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month.
Physical State :
Solid
Sequence :
Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Solubility :
Soluble in DMSO (20 mM), and DMF.
Storage :
Store at -20° C
Boiling Point :
~914.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
IC50 :
caspase-3 : IC50 = 130 nM
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD23380217
SMILES :
CC(C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)OC)C(=O)CF)NC(=O)[[email protected]](CCC(=O)OC)NC(=O)[[email protected]](CC(=O)OC)NC(=O)OCC1=CC=CC=C1

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Z-DEVD-FMK (CAS 210344-95-9)  Product Citations

See how others have used Z-DEVD-FMK (CAS 210344-95-9). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 56 total

PMID: 30692621 | SERPINB1-mediated checkpoint of inflammatory caspase activation. | Choi, YJ. et al. 2019. Nat. Immunol. 20: 276-287.

Citations 1 to 10 of 56 total

What is the solubility of this compound?

Asked by: two2igm05
Thank you for your question. This chemical, Z-DEVD-FMK: sc-311558, is soluble in DMSO and DMF at ≥20mM.
Answered by: Chemical Support 2
Date published: 2017-02-24

Can this product be used in HPLC analysis?

Asked by: SCchem16
Thank you for your question. This chemical, Z-DEVD-FMK (CAS 210344-95-9), is suitable to be analyzed by HPLC.
Answered by: Chemical Support 2
Date published: 2017-02-24
  • y_2023, m_2, d_4, h_21CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.34
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_2
  • loc_en_US, sid_311558, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 108ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Chen Chen, X. et al. (PubMed 26367448) used Z-DEVD-FMK, an inhibitor of caspase-3, caspase-6, caspase-7, and caspase-10, to demonstrate the involvment of caspase-3/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells. -SCBT Publication Review
Date published: 2015-02-17
  • y_2023, m_2, d_4, h_21
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.34
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_311558, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT