YM 976An inhibitor of PDE4

YM 976 (CAS 191219-80-4)

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Synonym: 4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one
Application: An inhibitor of PDE4
CAS Number: 191219-80-4
Purity: ≥98%
Molecular Weight: 313.79
Molecular Formula: C17H16ClN3O
* Refer to Certificate of Analysis for lot specific data (including water content).
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YM 976 is an inhibitor of PDE4 (phosphodiesterase 4) (IC50 = 2.2 nM), which is an enzyme responsible for hydrolyzing cyclic phosphodiesters in the secondary messenger molecule cAMP. This allows the secondary messenger to have a longer half life and thus increases the length and intensity of signal transduction.


References

Aoki et al (2000) A novel phosphodiesterase type 4 inhibitor, YM976 (4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one), with little emetogenic activity. J.Pharmacol.Exp.Ther. 295 255. Aoki et al (2001) Studies on mechanisms of low emetogenicity of YM976, a novel phosphodiesterase type 4 inhibitor. J.Pharmacol.Exp.Ther. 298 1142. Moriuchi et al (2003) Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur.J.Pharmacol. 470 57.

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mM), and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
132.7-134.0° C (lit.)
Boiling Point :
~485.38° C at 760 mmHg (Predicted)
Density :
~1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
PDE4: IC50 = 2.2 nM; PDE4A: IC50 = 5.01 nM (human)
pK Values :
pKb: 2.11 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UV1162150
PubChem CID :
6604918
MDL Number :
MFCD04113219
SMILES :
CCC1=NC2=C(C=C1)C(=NC(=O)N2CC)C3=CC(=CC=C3)Cl

Download SDS (MSDS)

Certificate of Analysis

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