YM 155An inhibitor of survivin expression and apoptosis inducer

YM 155 (CAS 781661-94-7)

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Synonym: 1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide
Application: An inhibitor of survivin expression and apoptosis inducer
CAS Number: 781661-94-7
Purity: >96%
Molecular Weight: 443.29
Molecular Formula: C20H19BrN4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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YM155 is a small molecule inhibitor of survivin expression that acts by inhibiting the survivin gene promoter transcription. Shown to induce apoptosis and inhibit tumor growth.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (>89 mg/ml), DMSO (>89 mg/ml), ethanol (>24 mg/ml), DMF (~3 mg/ml), and PBS (pH 7.2) (~10 mg/ml).
Storage :
Store at -20° C
IC50 :
Survivin promoter activity: IC50 = 0.54 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11178236
MDL Number :
MFCD11983133
SMILES :
CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. YM 155, sc-364661, is in yellow powder form.
Answered by: Chemical Support 4
Date published: 2017-05-05
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