YIC-C8-434 is an Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor.
Ohishi, K., et al., Inhibitory effects of N-(3,5-dimethoxy-4-n-octyloxycinnamoyl)-N'-(3,4-dimethylphenyl)piperazine (YIC-C8-434), an acyl-CoA:cholesterol O-acyltransferase inhibitor, on cholesterol esterification in the intestine and liver. Biol. Pharm. Bull. 26, 1125-1128, (2003) Kaneko, K., et al., Sex-dependent toxicity of a novel acyl-CoA:cholesterol acyltransferase inhibitor, YIC-C8-434, in relation to sex-specific forms of cytochrome P450 in rats. Toxicol. Sci. 64, 259-268, (2001);
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