Y-27152A prodrug of the KATP (Kir6) channel opener Y-26763

Y-27152 (CAS 127408-30-4)

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Synonym: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide
Application: A prodrug of the KATP (Kir6) channel opener Y-26763
CAS Number: 127408-30-4
Molecular Weight: 366.41
Molecular Formula: C21H22N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Y-27152 is a prodrug of the KATP (Kir6) channel opener Y-26763. Y-27152 is inactive in vitro, because it fails to modify tension in contracted aortic rings at concentrations up to 1 mM.


References

Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197.

Physical State :
Solid
Solubility :
Soluble to 5 mM in Ethanol and to 25 mM in DMSO
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6918184
SMILES :
CC(=O)N(C1C(C(OC2=C1C=C(C=C2)C#N)(C)C)O)OCC3=CC=CC=C3

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Certificate of Analysis

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