Y-27152 is a prodrug of the KATP (Kir6) channel opener Y-26763. Y-27152 is inactive in vitro, because it fails to modify tension in contracted aortic rings at concentrations up to 1 mM.
Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197.
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