Y-26763 is a KATP (Kir6) channel opener and active metabolite of Y-27152. In vitro, causes relaxation of contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells.
Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197. Cosgrove et al (2004) Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic b-cells. Eur.J.Pharmacol. 486 133.
Soluble in 1eq. NaOH (100 mM).
Store at room temperature
197.11° C (Predicted)
~455.4° C at 760 mmHg (Predicted)
~1.4 g/cm3 (Predicted)
n20D 1.62 (Predicted)
Relaxes contracted rat aortic rings: IC50 = 27 µM
pKa: 8.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Cosgrove et alCosgrove et al. (PubMed ID 14975702) found that the K(ATP) channel activator, Y-26763, inhibited both glucose- and tolbutamide-induced insulin secretion from human pancreatic beta-cells. -SCBT Publication Review
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