Y-26763A KATP (Kir6) channel opener

Y-26763 (CAS 127408-31-5)

Y-26763 | CAS 127408-31-5 is rated 5.0 out of 5 by 1.
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Synonym: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide
Application: A KATP (Kir6) channel opener
CAS Number: 127408-31-5
Purity: >98%
Molecular Weight: 276.29
Molecular Formula: C14H16N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Y-26763 is a KATP (Kir6) channel opener and active metabolite of Y-27152. In vitro, causes relaxation of contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells.


References

Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197. Cosgrove et al (2004) Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic b-cells. Eur.J.Pharmacol. 486 133.

Physical State :
Solid
Solubility :
Soluble in 1eq. NaOH (100 mM).
Storage :
Store at room temperature
Melting Point :
197.11° C (Predicted)
Boiling Point :
~455.4° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Relaxes contracted rat aortic rings: IC50 = 27 µM
pK Values :
pKa: 8.69 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
121878
MDL Number :
MFCD00888284
SMILES :
CC(=O)N([C@H]1[C@@H](C(OC2=C1C=C(C=C2)C#N)(C)C)O)O

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Certificate of Analysis

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Rated 5 out of 5 by from Cosgrove et al Cosgrove et al. (PubMed ID 14975702) found that the K(ATP) channel activator, Y-26763, inhibited both glucose- and tolbutamide-induced insulin secretion from human pancreatic beta-cells. -SCBT Publication Review
Date published: 2015-05-31
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