Y 134 is a selective estrogen receptor modulator (SERM), selective for ERα. Non cross-reactive with mineralocorticoid, glucocorticoid, androgen, and progesterone receptors. Y 134 exhibits agonist behaviors in bone and antagonist behavior in reproductive tissue. Y 134 decreases activity of estrogen-stimulated proliferation of ER+ human breast cancer MCF-7 and T47D cells.
Yang et al (2005) Benzothiophenes containing a piperazine side chain as selective ligands for the estrogen receptor a and their bioactivities in vivo. Bioorg.Med.Chem.Lett. 15 1505. Ning et al (2007) Biological activities of a novel selective oestrogen receptor modulator derived from raloxifene (Y134). Br.J.Pharmacol. 150 19.
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