Xylometazoline hydrochloride (CAS 1218-35-5)
Alternate Names:
2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline hydrochloride
Application:
Xylometazoline hydrochloride is α-adrenoceptor agonist
CAS Number:
1218-35-5
Purity:
≥98%
Molecular Weight:
280.84
Molecular Formula:
C16H24N2•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Xylometazoline hydrochloride, α-adrenoceptor agonist; imidazoline binding site ligand. Xylometazoline hydrochloride is an activator of α1A-AR, α1B-AR, α1D-AR, α2A-AR, α2B-AR and α2C-AR.
References
Sakuta, H., and Okamoto, K., Inhibition by imidazoline and imidazolidine derivatives of glibenclamide-sensitive K+ currents in Xenopus oocytes. Eur. J. Pharmacol. 259, 223-231, (1994) Bognar, I.T., et al., å-adrenoceptor mediated facilitation of acetylcho
Physical State
:
Solid
Solubility
:
Soluble in ethanol (100 mg/ml), and DMSO (27 mg/ml at 25° C).
Storage
:
Store at room temperature
Refractive Index
:
n20D ~1.54 (Predicted)
IC50
:
α1A-AR: IC50 = 0.08 µM; α2C-AR: IC50 = 0.22 µM; α1D-AR: IC50 = 0.45 µM; α1B-AR: IC50 = 0.56 µM; α2A-AR: IC50 = 0.98 µM
Ki Data
:
SR-1D: Ki= 0.7 nM (human); SR-1B: Ki= 13 nM (human); α1A-AR: Ki= 91 nM (human); Adrenergic receptor α: Ki= 91 nM (huamn); Adrenergic receptor α-2: Ki>500 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany
:
3
RTECS
:
NJ2390000
PubChem CID
:
Merck Index
:
14: 10086
MDL Number
:
MFCD00238707
EC Number
:
214-936-4
SMILES
:
CC1=CC(=CC(=C1CC2=NCCN2)C)C(C)(C)C.Cl
Download SDS (MSDS)
Certificate of Analysis
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