Xylometazoline hydrochloride CAS: 1218-35-5
MF: C16H24N2•HCl
Xylometazoline hydrochloride is α-adrenoceptor agonist.

Xylometazoline hydrochloride (CAS 1218-35-5)

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Alternate Names: 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline hydrochloride
Application: Xylometazoline hydrochloride is α-adrenoceptor agonist
CAS Number: 1218-35-5
Purity: ≥98%
Molecular Weight: 280.84
Molecular Formula: C16H24N2•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Xylometazoline hydrochloride, α-adrenoceptor agonist; imidazoline binding site ligand. Xylometazoline hydrochloride is an activator of α1A-AR, α1B-AR, α1D-AR, α2A-AR, α2B-AR and α2C-AR.


References

Sakuta, H., and Okamoto, K., Inhibition by imidazoline and imidazolidine derivatives of glibenclamide-sensitive K+ currents in Xenopus oocytes. Eur. J. Pharmacol. 259, 223-231, (1994) Bognar, I.T., et al., å-adrenoceptor mediated facilitation of acetylcho

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mg/ml), and DMSO (27 mg/ml at 25° C).
Storage :
Store at room temperature
Refractive Index :
n20D ~1.54 (Predicted)
IC50 :
α1A-AR: IC50 = 0.08 µM; α2C-AR: IC50 = 0.22 µM; α1D-AR: IC50 = 0.45 µM; α1B-AR: IC50 = 0.56 µM; α2A-AR: IC50 = 0.98 µM
Ki Data :
SR-1D: Ki= 0.7 nM (human); SR-1B: Ki= 13 nM (human); α1A-AR: Ki= 91 nM (human); Adrenergic receptor α: Ki= 91 nM (huamn); Adrenergic receptor α-2: Ki>500 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NJ2390000
PubChem CID :
Merck Index :
14: 10086
MDL Number :
MFCD00238707
EC Number :
214-936-4
SMILES :
CC1=CC(=CC(=C1CC2=NCCN2)C)C(C)(C)C.Cl

Download SDS (MSDS)

Certificate of Analysis

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