XE 991 dihydrochloride is a potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks KCNQ2+3/M-currents (IC50 = 0.6-0.98 μM) and KCNQ1 homomeric channels (IC50 = 0.75 μM) but is less potent against KCNQ1/minK channels (IC50 = 11.1 μM).
1. Wang, H.S., et al. 1998. Science. 282: 1890-1893. PMID: 9836639 2. Zaczek, R., et al. 1998. J.Pharmacol.Exp.Ther. 285: 724-730. PMID: 9580619 3. Wang, H.S., et al. 2000. Mol.Pharmacol. 57: 1218-1223. PMID: 10825393 4. Passmore, G.M., et al. 2003. J.Neurosci. 23: 7227-7236. PMID: 12904483
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Font nFont n-Lozano, A. et al. (PubMed 19921704) reported that the potent & selective inhibitor of KCNQ voltage-gated K-channels XE991, decreases the stimulation threshold for long-term synaptic plasticity in healthy mice and in models of cognitive disease. -SCBT Publication Review
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