XE 991 dihydrochlorideA potent & selective inhibitor of KCNQ voltage-gated K-channels

XE 991 dihydrochloride (CAS 122955-42-4)

XE 991 dihydrochloride | CAS 122955-42-4 is rated 5.0 out of 5 by 1.
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Synonym: 10,10-bis(4-Pyridinylmethyl)-9(10H)-anthracenone dihydrochloride
Application: A potent & selective inhibitor of KCNQ voltage-gated K-channels
CAS Number: 122955-42-4
Purity: ≥99%
Molecular Weight: 449.37
Molecular Formula: C26H20N2O•2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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XE 991 dihydrochloride is a potent and selective blocker of KCNQ voltage-gated potassium channels. Blocks KCNQ2+3/M-currents (IC50 = 0.6-0.98 μM) and KCNQ1 homomeric channels (IC50 = 0.75 μM) but is less potent against KCNQ1/minK channels (IC50 = 11.1 μM).


References

1. Wang, H.S., et al. 1998. Science. 282: 1890-1893. PMID: 9836639
2. Zaczek, R., et al. 1998. J.Pharmacol.Exp.Ther. 285: 724-730. PMID: 9580619
3. Wang, H.S., et al. 2000. Mol.Pharmacol. 57: 1218-1223. PMID: 10825393
4. Passmore, G.M., et al. 2003. J.Neurosci. 23: 7227-7236. PMID: 12904483

Physical State :
Solid
Solubility :
Soluble in DMSO (12 mg/mL).
Storage :
Desiccate at 4° C
IC50 :
KCNQ1/minK channels: IC50 = 11.1 µM; KCNQ2+3/M-currents: IC50 = 0.6-0.98 µM; KCNQ1 homomeric channels: IC50 = 0.75 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
CB1530000
PubChem CID :
45073462
SMILES :
C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3C2(CC4=CC=NC=C4)CC5=CC=NC=C5.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Font n Font n-Lozano, A. et al. (PubMed 19921704) reported that the potent & selective inhibitor of KCNQ voltage-gated K-channels XE991, decreases the stimulation threshold for long-term synaptic plasticity in healthy mice and in models of cognitive disease. -SCBT Publication Review
Date published: 2015-06-19
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