XCT790 is a potent and specific inverse agonist of ERRα. XCT790 shows no significant antagonist activity on related nuclear receptors, such as ERR or ERα at concentrations below 10 µM. This also inhibits the constitutive activity of ER (Estrogen Receptor).
Busch, B.B., et al., Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor å. J. Med. Chem. 47, 5593-5596, (2004)