XAF1 Antibody (B-5) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
raised against amino acids 1-225 mapping at the N-terminus of XAF1 of human origin
recommended for detection of XAF1 of human origin by WB, IP, IF and ELISA
m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) and m-IgG1 BP-HRP (mouse IgG1 binding protein-HRP) are the preferred secondary detection reagents for XAF1 Antibody (B-5) for WB applications. These reagents are now offered in bundles with XAF1 Antibody (B-5) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
X-linked inhibitor of apoptosis protein (XIAP)-associated factor 1 (XAF1) is a zinc finger protein that blocks the anti-apoptotic activity of XIAP. XIAP is a member of the family of intrinsic inhibitors of apoptosis proteins (IAPs), which suppress apoptosis through the inhibition of caspases. In the presence of XAF1, XIAP protein redistributes from the cytosol to the nucleus. XAF1 transcripts (3.9-, 4.5-, 6.0- and 7.0-kb) are present at high levels in heart and ovary. Low expression of XAF1 mRNA is an indicator for certain cancers (WM164 melanoma, WM35 melanoma, U937 pro-monocytic leukemia and HT1080 fibrosarcoma), suggesting that low levels of XAF1 transcript may enhance cancer cell-survival through the relative increase in XIAP anti-apoptotic function. IFN-α and IFN-β activate the human XAF1 gene, which maps to chromosome 17p13.2.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.