WS 12A potent TRPM8 agonist

WS 12 (CAS 68489-09-8)

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Synonym: Cyclohexanecarboxamide,N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-
Application: A potent TRPM8 agonist
CAS Number: 68489-09-8
Purity: ≥98%
Molecular Weight: 289.41
Molecular Formula: C18H27NO2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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WS 12 is a cooling agent and potent TRPM8 agonist (EC50 = 193 nM).


References

1. Beck, B. et al. 2007. Cell Calcium. 41(3): 285-294. PMID: 16949669
2. Bödding, M. et al. 2007. Cell Calcium. 42(6): 618-628. PMID: 17517434

Physical State :
Solid
Solubility :
Soluble in DMSO (>20 mg/ml), ethanol (75 mM), methanol, and DMF. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
163.47° C (Predicted)
Boiling Point :
~447.8° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
Optical Activity :
α20/D -50.4°, c = 0.25 in ethanol
IC50 :
TRPM8: EC5050 = 193 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11266244
MDL Number :
MFCD11100191
SMILES :
C[C@@H]1CC[C@H]([C@@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C

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Certificate of Analysis

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