WS 12 CAS: 68489-09-8
MF: C18H27NO2
MW: 289.41
A potent TRPM8 agonist.

WS 12 (CAS 68489-09-8)

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Alternate Names: Cyclohexanecarboxamide,N-(4-methoxyphenyl)-5-methyl-2-(1-methylethyl)-, (1R,2S,5R)-
Application: WS 12 is a potent TRPM8 agonist
CAS Number: 68489-09-8
Purity: ≥98%
Molecular Weight: 289.41
Molecular Formula: C18H27NO2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

WS 12 is a cooling agent and potent TRPM8 agonist (EC50 = 193 nM).


References

1. Beck, B. et al. 2007. Cell Calcium. 41(3): 285-294. PMID: 16949669
2. Bödding, M. et al. 2007. Cell Calcium. 42(6): 618-628. PMID: 17517434

Physical State :
Solid
Solubility :
Soluble in DMSO (>20 mg/ml), ethanol (75 mM), methanol, and DMF. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
163.47° C (Predicted)
Boiling Point :
~447.8° C at 760 mmHg (Predicted)
Density :
~1.0 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
Optical Activity :
α20/D -50.4°, c = 0.25 in ethanol
IC50 :
TRPM8: EC5050 = 193 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11266244
MDL Number :
MFCD11100191
SMILES :
C[[email protected]@H]1CC[[email protected]]([[email protected]@H](C1)C(=O)NC2=CC=C(C=C2)OC)C(C)C

Download SDS (MSDS)

Certificate of Analysis

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Hello, I am interested in both WS-5 and WS-12 at 10mg each, and I need to know what form that it comes in, and, if in powder form, is it soluble in propylene glycol? What are the smallest quantities available to purchase? Are samples available? Thank-you.

Asked by: Liana
Thank you for your question. This information can vary for each lot, please reach out to Technical Service for accurate information.
Answered by: Tech Service
Date published: 2020-01-13
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