An anti-inflammatory agent and inhibitor of COX-2, which blocks the induction of both COX-2 and iNOS. Wogonin inhibits COX-2 (IC50 = 46 µM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. S
Park, et al. Eur. J. Pharmacol. 425, 153-157, (2001); Chi, et al. Biochem. Pharmacol. 61, 1195-1203, (2001); Kim, et al. Neurosci. Lett. 309, 67-71, (2001)
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