WIN 64338 hydrochlorideA bradykinin B2 R Inhibitor

WIN 64338 hydrochloride (CAS 163727-74-0)

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Synonym: (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride
Application: A bradykinin B2 R Inhibitor
CAS Number: 163727-74-0
Molecular Weight: 783.94
Molecular Formula: C45H68ClN4OP•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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WIN 64338 hydrochloride is a bradykinin B2 R Inhibitor.


References

Scherrer et al (1995) Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea. Br.J.Pharmacol. 115 1127. Marceau et al (1994) Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin. J.Pharmacol.Exp.Ther. 269 1136. Hu et al (2004) Action of bradykinin in the submucosal plexus of guinea pig small intestine. J.Pharmacol.Exp.Ther. 309 320.

Physical State :
Solid
Solubility :
Soluble in DMSO (75 mM).
Storage :
Desiccate at 4° C
Ki Data :
bradykinin B2 R: Ki= 60 nM (human); Muscarinic acetylcholine receptor: Ki= 350 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9832172
MDL Number :
MFCD06804619
SMILES :
CCCC[P+](CCCC)(CCCC)CC1=CC=C(C=C1)NC(=O)[C@H](CC2=CC3=CC=CC=C3C=C2)NC(=NC4CCCCC4)NC5CCCCC5.Cl.[Cl-]

Download SDS (MSDS)

Certificate of Analysis

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