WAY 629 hydrochlorideA selective SR-2C agonist

WAY 629 hydrochloride (CAS 57756-45-3)

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Application: A selective SR-2C agonist
CAS Number: 57756-45-3
Purity: >98%
Molecular Weight: 262.78
Molecular Formula: C15H18N2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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WAY 629 hydrochloride is a selective SR-2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant SR-2C, SR-2A, SR-6 and SR-7, respectively. WAY 629 hydrochloride stimulates intracellular Ca2+ mobilization in CHO cells expressing human SR-2C (EC50 = 72 nM).


References

Sabb et al (2004) Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg.Med.Chem.Lett. 14 2603. Dunlop et al (2004) Identification of cycloalkyl[b][1,4]benzodiazepinoindoles as novel 5-HT2C receptor agonists. Fund.Clin.Pharmacol. 18 Suppl.1 145.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Desiccate at 4° C
Boiling Point :
460.5° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.71 (Predicted)
IC50 :
SR-2C: EC5050 = 72 nM (human)
Ki Data :
SR-2C: Ki= 56 nM (human); SR-7: Ki= 0.82 µM (human); SR-6: Ki= 1.58 µM (human); SR-2A: Ki= 2.35 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
12259556
SMILES :
C1CCC2=C(C1)C3=C4N2CCNCC4=CC=C3.Cl

Download SDS (MSDS)

Certificate of Analysis

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