WAY 629 hydrochloride is a selective SR-2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant SR-2C, SR-2A, SR-6 and SR-7, respectively. WAY 629 hydrochloride stimulates intracellular Ca2+ mobilization in CHO cells expressing human SR-2C (EC50 = 72 nM).
Sabb et al (2004) Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg.Med.Chem.Lett. 14 2603. Dunlop et al (2004) Identification of cycloalkyl[b][1,4]benzodiazepinoindoles as novel 5-HT2C receptor agonists. Fund.Clin.Pharmacol. 18 Suppl.1 145.
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