WAY 262611A WNT pathway agonist

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WAY 262611

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Synonym: DKK1 inhibitor; (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine

Application: A WNT pathway agonist

Purity: ≥97%

Molecular Weight: 318.42

Molecular Formula: C₂₀H₂₂N₄

* Refer to Certificate of Analysis for lot specific data (including water content).

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• Description
• Technical Information
• Safety Information
• SDS & Certificate of Analysis

WAY 262611 is a Wnt pathway agonist acting via inhibition of DKK1 with no GSK-3β inhibition (IC₅₀ value >100 μM). TCF-Luciferase EC₅₀ = 0.63 μM.

Physical State :

Solid

Solubility :

Soluble in DMSO (30 mg/ml), or 100% ethanol (25 mg/ml).

Storage :

Store at -20° C

IC50 :

TCF-Luciferase: EC₅₀50 = 0.63 µM; Dkk-1: EC₅₀50 = 0.63 µM (human); GSK-3β: IC₅₀ > 100 µM (human)

pK Values :

pK_b: 10.13 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

25199517

SMILES :

C1CN(CCC1CN)C2=NC=CC(=N2)C3=CC4=CC=CC=C4C=C3

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Certificate of Analysis

Catalog Number sc-397019 sc-397019A

Lot Number

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WAY 262611  Product Citations

See how others have used WAY 262611. Click on the entry to view the PubMed entry .

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PMID: # 27864382  Sima, J. et al. 2016. Development.

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