WAY 213613A selective non-substrate inhibitor of EAAT2

WAY 213613 (CAS 868359-05-1)

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Synonym: N4-[4-(2-Bromo-4,5-difluorophenoxy)phenyl)]-L-asparagine
Application: A selective non-substrate inhibitor of EAAT2
CAS Number: 868359-05-1
Purity: ≥99%
Molecular Weight: 415.19
Molecular Formula: C16H13BrF2N2O4
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* Refer to Certificate of Analysis for lot specific data (including water content).
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WAY 213613 is a strong, non-substrate inhibitor of EAAT2 (GLT-1) that displays > 44-fold selectivity over EAAT1 and EAAT3 (IC50 values are 85, 3787 and 5004 nM for EAAT2, EAAT3 and EAAT1 respectively). WAY 213613 exhibits no activity towards metabotropic and ionotropic glutamate receptors.


References

1. Dunlop, J., et al. 2005. Mol. Pharmacol. 68: 974-982.
2. Beart, P.M. and O'Shea, R.D. 2007. Br. J. Pharmacol. 150: 5-17.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and 1eq. NaOH (100 mM).
Storage :
Store at 4° C
Melting Point :
318.46° C (Predicted)
Boiling Point :
~565.63° C at 760 mmHg (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
Optical Activity :
α20/D -6°, c = 1 in DMSO
IC50 :
EAAT2: IC50 = 80 nM (human); EAAT3: IC50 = 3.8 µM (human); EAAT1: IC50 = 5 µM (human)
pK Values :
pKa: 2.38 (Predicted), pKb: 8.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11531745
MDL Number :
MFCD09971111
SMILES :
O=C(Nc1ccc(cc1)Oc1cc(F)c(F)cc1Br)C[C@H](N)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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