WAY 208466 dihydrochlorideA high affinity, selective SR-6 (5-HT6) agonist

WAY 208466 dihydrochloride (CAS 633304-27-5)

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Synonym: 3-[(-3-Fluorophenyl)sulfonyl]-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-1-ethanamine dihydrochloride
Application: A high affinity, selective SR-6 (5-HT6) agonist
CAS Number: 633304-27-5
Purity: 98%
Molecular Weight: 420.33
Molecular Formula: C17H18FN3O2S•2HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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WAY 208466 dihydrochloride is a high affinity, selective SR-6 (5-HT6) receptor agonist with an EC50 of 7.3 nM at the human SR-6 (5-HT6) receptor. This compound has been shown to elevate cortical GABA levels in rat frontal cortex. WAY 208466 dihydrochloride is an activator of Serotonin.


References

1. Schechter, L.E., et al. 2008. Neuropsychopharmacology. 33: 1323-1335. PMID: 17625499
2. Carr, G.V., et al. 2010. Psychopharmacol. 213: 499-507. PMID: 20217056

Physical State :
Solid
Solubility :
Soluble in DMSO (80 mM), and water (80 mM).
Storage :
Desiccate at 4° C
Melting Point :
184.2-189.6° C
Refractive Index :
n20D ~1.61 (Predicted)
IC50 :
SR-6: EC5050 = 7.3 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
22028182
SMILES :
CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC=CC(=C3)F.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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