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WAY 161503 hydrochloride is a potent and selective SR-2C agonist (Ki = 4 nM; EC50 = 12 nM).
Rosenzweig-Lipson et al (2000) Antiobesity-like effects of the selective 5-HT2C agonist WAY 161503. FASEB J. 14 A1321. Welmaker et al (2000) Synthesis and 5-hydroxytryptamine (5-HT) activity of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5-(6H)ones and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoxalines. Bioorg.Med.Chem.Lett. 10 1991. Cryan and Lucki (2000) Antidepressant-like behavioral effects mediated by 5-hydroxytryptamine2C receptors. J.Pharmacol.Exp.Ther. 295 1120.
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